Document Detail

Relation of prescription nonsteroidal antiinflammatory drug use to cognitive function among community-dwelling elderly.
MedLine Citation:
PMID:  9099396     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the relationship of nonsteroidal antiinflammatory drug (NSAID) use to level of cognitive function in community-dwelling elderly persons. METHODS: The prospective cohort study included 2765 nonproxy subjects from the Duke University Established Populations for Epidemiologic Studies of the Elderly who were cognitively intact at baseline (1986-1987) and alive at follow-up three year later. Cognitive function was assessed by the Short Portable Mental Status Questionnaire (i.e., intact vs. impaired and change in score) and by the individual domains of the Orientation-Memory-Concentration Test (i.e., number of errors). NSAID use, determined from in-home interviews, was coded for chronicity, dose, frequency of use, and prescription status. RESULTS: After controlling for demographic factors as well as health status and behavior, continuous, regularly-scheduled, prescription use of NSAID was associated with preservation of one aspect of cognitive functioning: concentration (beta coefficient, 0.29; 95% confidence interval [CI] -0.54 to -0.04, indicating fewer errors). However, no consistent dose-response relationship was found. Current and prior NSAID use was unrelated to level of cognitive functioning across all five measures; among current users, those taking moderate or high doses (beta coefficient, 0.41; 95% CI, 0.08 to 0.74) made more errors on the memory test compared with those taking low doses (beta coefficient 0.03; 95% CI, -.85 to 0.91). CONCLUSIONS: These results suggest no substantial or consistent protective effect of prescription NSAID use on cognitive function in community-dwelling elderly. However, recent use at higher doses may be associated with memory deterioration in this population.
J T Hanlon; K E Schmader; L R Landerman; R D Horner; G G Fillenbaum; C F Pieper; W E Wall; M J Koronkowski; H J Cohen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of epidemiology     Volume:  7     ISSN:  1047-2797     ISO Abbreviation:  Ann Epidemiol     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-07-08     Completed Date:  1997-07-08     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  9100013     Medline TA:  Ann Epidemiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  87-94     Citation Subset:  IM    
Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC 27710, USA.
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MeSH Terms
Aged / psychology*
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Cognition / drug effects*
Cohort Studies
Data Collection
Data Interpretation, Statistical
Epidemiologic Methods
Health Status Indicators
Memory / drug effects
Mental Status Schedule
Neuropsychological Tests*
Prospective Studies
Grant Support
AG00526/AG/NIA NIH HHS; P60A-G11268//PHS HHS; R01-HS07819/HS/AHRQ HHS
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal

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