| Relation of prenatal phenylalanine exposure to infant and childhood cognitive outcomes: results from the International Maternal PKU Collaborative Study. | |
| | |
MedLine Citation:
|
PMID: 14654661 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The primary aims of this study were to model the form of the relation between prenatal exposure to phenylalanine (Phe) and measures of offspring intellectual development and to estimate the developmental relations of maternal demographic, pregnancy-related, and perinatal variables on offspring intelligence during infancy and childhood. METHODS: The participants were the 413 children and their mothers from the International Maternal PKU Collaborative Study. RESULTS: Results supported a nonlinear relation between prenatal Phe exposure and offspring cognitive outcomes, with damage to the developing fetus if average Phe levels are above approximately 360 micromol/L. Moreover, prenatal Phe exposure had a strong effect on offspring outcomes at 1 year of age and was the only one of the background, pregnancy-related, or perinatal variables to influence directly offspring outcomes at 2, 4, and 7 years of age. CONCLUSION: The present study was able to document the importance of prenatal exposure to Phe for predicting offspring cognitive outcomes in the presence of other predictors of these outcomes. |
| | |
Authors:
|
Keith F Widaman; Colleen Azen |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Pediatrics Volume: 112 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2003 Dec |
Date Detail:
|
Created Date: 2003-12-05 Completed Date: 2003-12-24 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
|
Languages: eng Pagination: 1537-43 Citation Subset: AIM; IM |
Affiliation:
|
Department of Psychology, University of California at Davis, Davis, California 95616-8686, USA. kfwidaman@ucdavis.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aptitude Tests Child Child Development Child, Preschool Female Humans Infant, Newborn Intelligence* Linear Models Longitudinal Studies Male Mental Retardation / etiology Models, Statistical Mutation Phenylalanine / blood* Phenylketonuria, Maternal / complications* Phenylketonurias / genetics Pregnancy Socioeconomic Factors |
| Grant Support | |
ID/Acronym/Agency:
|
N01-HD-2-3148/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
63-91-2/Phenylalanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Role of nutrition in pregnancy with phenylketonuria and birth defects.
Next Document: Cognitive and behavioral development in maternal phenylketonuria offspring.