Document Detail


Relation of osteoclast activating factor production to extent of bone disease in multiple myeloma.
MedLine Citation:
PMID:  7437344     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Measurements of total body myeloma cell number and osteoclast activating factor (OAF) production by bone marrow myeloma cells in vitro were made in 33 patients with plasma cell myeloma. There was a highly significant correlation (P < 0.001) between the amount of OAF produced by bone marrow myeloma cells and the extent of skeletal destruction. Serial studies indicated reduction of OAF production with remission induction and high OAF production at the time of relapse with new bone destruction. Although hypercalcaemia occurred only in patients with the most extensive bone lesions, there was no direct relationship between OAF production and the serum calcium concentration. These data suggest that measurement of OAF production in multiple myeloma may predict those patients at risk for development of extensive skeletal destruction due to this neoplasm.
Authors:
B G Durie; S E Salmon; G R Mundy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  British journal of haematology     Volume:  47     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-02-26     Completed Date:  1981-02-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  21-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bone Marrow / metabolism
Bone Resorption / etiology,  metabolism*
Cell Count
Cells, Cultured
Humans
Hypercalcemia / metabolism
Lymphokines / metabolism*
Multiple Myeloma / complications,  metabolism*
Osteoclasts / metabolism*
Grant Support
ID/Acronym/Agency:
AM-21584/AM/NIADDK NIH HHS; CA-17094/CA/NCI NIH HHS; CA-21839/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Lymphokines; 64060-24-8/osteoclast activating factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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