Document Detail

Relation of the number of metabolic syndrome risk factors with all-cause and cardiovascular mortality.
MedLine Citation:
PMID:  18773989     Owner:  NLM     Status:  MEDLINE    
The metabolic syndrome (MS) is a constellation of risk factors associated with diabetes and cardiovascular disease. This syndrome consists of at least 3 parameters assessing central obesity, hypertension, high-density lipoprotein cholesterol, triglycerides, and impaired glucose metabolism. Whether persons with 4 or 5 risk factors are at higher risk than those with 3 risk factors is unclear. Also unclear is whether those without the MS but with 1 or 2 risk factors warrant therapy. We assessed cardiovascular and all-cause mortality as a function of the number of these risk factors. We followed 30,365 men for a median follow-up of 13.6 years. During follow-up, 1,449 participants died, 527 from cardiovascular causes. All of the individual parameters defining the MS were significantly associated with both all-cause and cardiovascular mortality (p <0.001). After adjustment for age and the other MS variables, hypertension was the most potent risk factor whereas central obesity and hypertriglyceridemia remained associated with both all-cause and cardiovascular mortality. A highly significant trend was also noted between both all-cause or cardiovascular mortality and the number of risk factors (p <0.001 for trend). Risk increased incrementally, beginning at 1 risk factor for cardiovascular mortality and at 2 risk factors for all-cause mortality. In conclusion, there is a continuum of risk as the number of metabolic syndrome risk factors increases. These findings add to the growing evidence that central obesity can independently and adversely affect health.
John S Ho; John J Cannaday; Carolyn E Barlow; Tedd L Mitchell; Kenneth H Cooper; Shannon J FitzGerald
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-06-26
Journal Detail:
Title:  The American journal of cardiology     Volume:  102     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-08     Completed Date:  2008-10-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  689-92     Citation Subset:  AIM; IM    
Cooper Clinic, Dallas, Texas, USA.
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MeSH Terms
Blood Glucose / analysis
Cardiovascular Diseases / mortality*
Cholesterol, HDL / blood
Hypertension / epidemiology
Hypertriglyceridemia / epidemiology
Longitudinal Studies
Metabolic Syndrome X / epidemiology*
Middle Aged
Obesity / epidemiology
Risk Assessment
Risk Factors
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Cholesterol, HDL

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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