| Relation of non-cholesterol sterols to coronary risk factors and carotid intima-media thickness: the Cardiovascular Risk in Young Finns Study. | |
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MedLine Citation:
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PMID: 19963215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aim of the present study was to evaluate the role of cholesterol metabolism in the development of atheromatous artery disease. METHODS: Serum synthesis (cholesterol precursors) and absorption markers (cholestanol, campesterol, sitosterol, and avenasterol) were related to coronary risk factors and vascular structure in a population-based sample of 468 randomly selected 33-39-year-old men on their regular habitual diet. Carotid artery intima-media thickness (IMT) and serum lipids (including cholesterol) and sterols were measured in 2001, and the subjects were ranked to decreasing cholesterol synthesis depicted by serum cholestanol quartiles defined 21 years earlier in adolescence. RESULTS: Serum cholesterol was correlated with absorption (e.g. serum campesterol, p<0.05), but not with synthesis, or with cholestanol quartiles. Cholesterol metabolism (synthesis/absorption markers) decreased linearly (about 50%) with the increasing cholestanol quartiles. IMT differed between the age groups, but not between cholestanol quartiles. Serum triglycerides, apoprotein B, and body mass index decreased, and non-HDL cholesterol/apoprotein B values increased between the cholestanol quartiles, whereas LDL cholesterol was unchanged. Cholesterol synthesis markers were related to blood pressure and serum triglycerides, and negatively to HDL cholesterol level in total population and in most of the cholestanol quartiles (p from 0.05 to 0.001). CONCLUSIONS: Variables of metabolic syndrome accumulated in quartiles of high synthesis of cholesterol. Non-cholesterol sterols were related to many classic coronary risk factors, but virtually not to serum cholesterol or vascular structure. |
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Authors:
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Tatu A Miettinen; Helena Gylling; Maarit Hallikainen; Markus Juonala; Leena R?s?nen; Jorma Viikari; Olli T Raitakari |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-20 |
Journal Detail:
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Title: Atherosclerosis Volume: 209 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-26 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 592-7 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Medicine, Division of Internal Medicine, University of Helsinki, Helsinki, Finland. tatu.a.miettinen@helsinki.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Carotid Arteries / pathology*, ultrasonography Child Cholestanol / blood Cholesterol / analogs & derivatives, blood, metabolism* Coronary Disease / etiology*, pathology, ultrasonography Follow-Up Studies Humans Male Phytosterols / blood Risk Factors Sitosterols / blood Sterols / blood* Tunica Intima / pathology*, ultrasonography Tunica Media / pathology, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Phytosterols; 0/Sitosterols; 0/Sterols; 474-62-4/campesterol; 57-88-5/Cholesterol; 5779-62-4/sitosterol; 80-97-7/Cholestanol; 80-99-9/lathosterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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