Document Detail


Relation of myocardial blush grade to microvascular perfusion and myocardial infarct size after primary or rescue percutaneous coronary intervention.
MedLine Citation:
PMID:  17560873     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Angiographic myocardial blush grade (MBG) is a potent predictor of long-term outcome after percutaneous treatment of myocardial infarction, yet little is known regarding the underlying pathophysiologic features. The relation between MBG and cardiovascular magnetic resonance (CMR)-defined amounts of necrosis and microvascular obstruction was examined in 27 patients. Another powerful prognostic indicator, ST-segment resolution>70%, was correlated with other predictors. Increasing MBG was associated (p=0.001) in a linear fashion (p<0.001) with less microvascular obstruction using CMR, whereas the inverse relation with amount of necrosis, although significant (p=0.043), was nonlinear (p=0.36). ST resolution was not correlated with either MBG or CMR parameters. In conclusion, MBG is mainly influenced by microvascular patency and is less dependent on the amount of muscle necrosis, and the common practice of including MBG 2 and 3 into a single "patent microcirculation" category might not be justified. Moreover, the mechanisms of ST resolution should be searched for at the cellular level.
Authors:
Italo Porto; Francesco Burzotta; Marta Brancati; Carlo Trani; Antonella Lombardo; Enrico Romagnoli; Giampaolo Niccoli; Luigi Natale; Lorenzo Bonomo; Filippo Crea
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Publication Detail:
Type:  Journal Article     Date:  2007-05-02
Journal Detail:
Title:  The American journal of cardiology     Volume:  99     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-11     Completed Date:  2007-09-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1671-3     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, Rome, Italy. i.porto@doctors.org.uk
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MeSH Terms
Descriptor/Qualifier:
Aged
Angioplasty, Transluminal, Percutaneous Coronary*
Coronary Circulation / physiology*
Female
Heart / physiopathology
Humans
Magnetic Resonance Imaging, Cine
Male
Microcirculation / pathology*,  physiopathology
Middle Aged
Myocardial Infarction / pathology*,  physiopathology,  therapy
Myocardium / pathology*

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