Document Detail

Relation of myocardial blood volume to left ventricular function and future cardiac events in patients with idiopathic dilated cardiomyopathy.
MedLine Citation:
PMID:  14695466     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The hypothesis that myocardial blood volume is associated with left ventricular (LV) dysfunction and future cardiovascular events in patients with idiopathic dilated cardiomyopathy (IDC) was tested using intravenous myocardial contrast echocardiography (MCE). METHODS AND RESULTS: Thirty-five patients with IDC and 10 age-matched healthy control subjects were enrolled. Using MCE, background-subtracted and peak myocardial contrast intensity (calibrated PMCI) were calculated as measures of myocardial blood volume. LV ejection fraction (LVEF) was calculated using the modified Simpson method. Patients with IDC were stratified into 2 groups according to the median value of the calibrated PMCI [high value group (n=17): calibrated PMCI > or = -22.7 dB, low value group (n=18): calibrated PMCI < -22.7 dB]. The calibrated PMCI was markedly reduced in patients with IDC compared with the control subjects (p=0.0025) and closely related to LVEF (r=0.688, p<0.0001). In the multivariate model, calibrated PMCI was the independent variable that predicted cardiac events in patients with IDC. According to the Kaplan-Meier analysis, cardiac event-free rates were significantly lower in the low-value group than in the high-value group (p<0.01). CONCLUSIONS: Myocardial blood volume is closely related to LV dysfunction and future cardiac events in patients with IDC.
Katsuji Inoue; Mareomi Hamada; Tomoaki Ohtsuka; Jitsuo Higaki
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  68     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-25     Completed Date:  2004-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  53-8     Citation Subset:  IM    
The Second Department of Internal Medicine, Ehime University School of Medicine, Japan.
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MeSH Terms
Blood Volume*
Cardiomyopathy, Dilated / blood,  complications,  physiopathology*
Coronary Angiography
Coronary Circulation / physiology*
Follow-Up Studies
Heart Diseases / epidemiology*
Image Processing, Computer-Assisted
Middle Aged
Patient Selection
Predictive Value of Tests
Reference Values
Regression Analysis
Thallium Radioisotopes / diagnostic use
Time Factors
Tomography, Emission-Computed, Single-Photon
Ventricular Function, Left / physiology*
Reg. No./Substance:
0/Thallium Radioisotopes

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