Document Detail

Relation of measured brain glucose utilisation and cerebral atrophy in man.
MedLine Citation:
PMID:  3497229     Owner:  NLM     Status:  MEDLINE    
The effect of cerebral atrophy on measured cerebral metabolic rates for glucose (CMRglc), as determined with positron emission tomography (PET), was examined in 49 healthy males aged 21-83 years. Global CMRglc and regional CMRglc for 34 grey matter regions parallel to and from 30 to 80 mm above the inferior orbital meatal (IOM) line were measured under resting conditions, using [18F]-fluorodeoxyglucose and an ECAT II positron emission tomograph. Using a GE 8800 CT/T scanner, slices parallel to and from 30 to 80 mm above the IOM line were analysed for CSF volume. Cerebral atrophy, indicated by increased CSF volume, was correlated significantly with global CMRglc, but accounted for no more than 13% of the variance in the CMRglc measurements. Methods for correcting for inter-subject variation in CSF volume were proposed. Global values for CMRglc, uncorrected or corrected for CSF volume, were found to be age invariant. These findings indicate that (a) cerebral atrophy has a small, but statistically significant effect on CMRglc as measured with PET; (b) CMRglc is age invariant in healthy males.
N L Schlageter; B Horwitz; H Creasey; R Carson; R Duara; G W Berg; S I Rapoport
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  50     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-09-02     Completed Date:  1987-09-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  779-85     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Aging / metabolism*,  pathology
Brain / metabolism*,  pathology,  radionuclide imaging
Deoxyglucose / analogs & derivatives,  diagnostic use
Fluorodeoxyglucose F18
Glucose / metabolism*
Middle Aged
Tomography, Emission-Computed
Reg. No./Substance:
154-17-6/Deoxyglucose; 50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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