| Relation of left-ventricular dyssynchrony by phase analysis of gated SPECT images and cardiovascular events in patients with implantable cardiac defibrillators. | |
| | |
MedLine Citation:
|
PMID: 20300907 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Left-ventricular (LV) dyssynchrony could be measured by gated SPECT myocardial perfusion imaging (MPI). This study examined the relation between the degree of dyssynchrony and outcome in patients with implantable cardiac defibrillators (ICDs). METHODS AND RESULTS: We studied 70 patients with ICD and LV ejection fraction (EF) <.40 by gated MPI (performed within 6 weeks of the device implantation). The images were re-processed using phase analysis to derive phase standard deviation (SD) and histogram bandwidth. All-cause mortality and appropriate ICD shocks were identified as the primary endpoint. There were 87% men, aged 62 +/- 11 years. The EF was 26 +/- 8% (range 12%-39%). The phase SD was 51 degrees +/- 20 degrees (range 12 degrees -99 degrees ) and the histogram bandwidth was 157 degrees +/- 72 degrees (range 21 degrees -327 degrees ). The SD and bandwidth were significantly greater than corresponding values in patients with normal EF (15.8 +/- 11.8 degrees and 42.0 +/- 28.4 degrees , respectively, P < .0001, each). At 1 year, 8 patients (11%) died or had shocks. The patients with events had higher phase SD than those without events (60 +/- 5 degrees vs 50 +/- 21 degrees , P = .002). The histogram bandwidth was also higher in those with events (185 +/- 37 vs 154 +/- 75, P = .07). All patients with event had a phase SD >or= 50 degrees , while none of the patients with a phase SD < 50 degrees (N = 26) had an event (P = .02). CONCLUSIONS: The severity of LV dyssynchrony by phase analysis in patients with LV dysfunction, and ICD is associated with increased risk of death and appropriate ICD shock; a phase SD < 50 degrees was associated with no events at 1 year. |
| | |
Authors:
|
Wael A Aljaroudi; Fadi G Hage; Daniel Hermann; Harish Doppalapudi; Rajesh Venkataraman; Jaekyeong Heo; Ami E Iskandrian |
Related Documents
:
|
131657 - Echocardiography in wolff-parkinson-white syndrome. 14715337 - Use of tissue doppler imaging to facilitate the prediction of events in patients with a... 6691357 - Improvement in depressed cardiac function in hypertensive patients during pindolol trea... 12442927 - Doppler indices of diastolic transmitral flow velocity are invalid indicators of myocar... 6726717 - Involvement of the urinary bladder in systemic lupus erythematosus. a pathologic study. 7065087 - Convergence-evoked eyelid nystagmus. |
Publication Detail:
|
Type: Journal Article Date: 2010-03-19 |
Journal Detail:
|
Title: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology Volume: 17 ISSN: 1532-6551 ISO Abbreviation: J Nucl Cardiol Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-11 Completed Date: 2010-08-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9423534 Medline TA: J Nucl Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 398-404 Citation Subset: IM |
Affiliation:
|
Division of Cardiovascular Diseases, Department of Medicine, University of Alabama at Birmingham, 318 LHRB, 1900 University BLVD, Birmingham, AL 35294-0006, USA. wjaroudi@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography* Defibrillators, Implantable* Female Humans Male Middle Aged Myocardial Perfusion Imaging* Ventricular Dysfunction, Left / radionuclide imaging, therapy* |
| Comments/Corrections | |
Comment In:
|
J Nucl Cardiol. 2010 Jun;17(3):354-8
[PMID:
20387136
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Impact of weight on long-term survival among patients without known coronary artery disease and a no...
Next Document: Physical exercise attenuates MPTP-induced deficits in mice.