Document Detail

Relation of increased chromosomal damage to future adverse cardiac events in patients with known coronary artery disease.
MedLine Citation:
PMID:  18993144     Owner:  NLM     Status:  MEDLINE    
Somatic deoxyribonucleic acid (DNA) damage has been associated with early-phase and/or acute complications of atherosclerosis. However, it remains unclear whether circulating levels of DNA damage have prognostic value in patients with coronary artery disease (CAD). The aim of this study was to assess the prognostic significance of chromosomal DNA damage in human lymphocytes on the rate of major adverse cardiovascular events in patients with CAD. A follow-up prospective cohort study was carried out of 178 patients (153 men, mean age 61.9 +/- 9.7 years) with angiographically proved CAD who underwent micronucleus assay, a sensitive biomarker of chromosomal damage and genetic instability, from March 1999 and June 2001. During a mean follow-up period of 51.4 +/- 23.8 months, 58 patients had major adverse cardiovascular events (cardiac death, myocardial infarction, stroke, congestive heart failure, unstable angina, or coronary and peripheral revascularization). The overall event-free survival rates were 77.5%, 70.4%, and 49.0% in patients in the lower, middle, and upper tertiles of micronucleus level, respectively (log rank = 11.5, p = 0.003). In a multivariate Cox regression model, only the upper tertiles were significantly associated with a higher risk for major adverse cardiovascular events (hazard ratio 2.2, 95% confidence interval 1.1 to 4.7, p = 0.03). In conclusion, levels of peripheral chromosomal DNA damage may be a new sensitive biomarker of prognostic stratification in patients with known CAD.
Chiara Federici; Nicoletta Botto; Samantha Manfredi; Antonio Rizza; Martina Del Fiandra; Maria Grazia Andreassi
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Publication Detail:
Type:  Journal Article     Date:  2008-09-05
Journal Detail:
Title:  The American journal of cardiology     Volume:  102     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-10     Completed Date:  2008-12-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1296-300     Citation Subset:  AIM; IM    
CNR, Institute of Clinical Physiology, Gabriele Monasterio Foundation, Massa, Italy.
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MeSH Terms
Chromosome Breakage*
Coronary Artery Disease / blood,  complications*,  genetics*
Follow-Up Studies
Heart Diseases / blood,  genetics*
Micronucleus Tests
Middle Aged
Prospective Studies

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