Document Detail

Relation of in vitro growth characteristics to cytogenetics and treatment outcome in acute myeloid leukemia: prognostic significance in patients with a normal karyotype.
MedLine Citation:
PMID:  14604283     Owner:  NLM     Status:  MEDLINE    
We analyzed in vitro growth characteristics of bone marrow mononuclear cells (BMMCs) from 322 patients with acute myeloid leukemia (AML) in relation to cytogenetic abnormalities. Median colony growth was low in each of the cytogenetic changes associated with a favorable outcome. Most karyotypic abnormalities in the intermediate prognosis group were associated with low growth potential, but 11 q23 abnormalities exhibited 8 times higher in vitro growth. Cytogenetic changes that included abn(3q) seemed to display the highest colony growth in the unfavorable prognosis group, whereas isolated -7 may have been associated with limited growth potential. In vitro growth behavior was predictive of neither rate of complete remission (CR) nor survival of AML patients within the 3 cytogenetic risk groups. In contrast, colony growth differed significantly in the subgroup of patients with a normal karyotype who achieved remission with induction treatment and those who had no remission (10 versus 81.5/10(5) BMMCs; P = .015). Significantly more patients with normal cytogenetics and colony growth below the 50th percentile went into CR than did patients with colony growth above the 50th percentile (82.8% versus 71.2%). Only 4 (6.8%) of the patients in the low growth group had no remission, compared with 12 (23.1%) of the patients with higher in vitro growth (P = .031, chi-square test). In conclusion, colony growth may prove useful as a prognostic factor for early treatment failure in AML patients with a normal karyotype.
Andrea Berer; Birgit Kainz; Ulrich Jäger; Eva Jäger; Susanna Stengg; Berthold Streubel; Christa Fonatsch; Gerlinde Mitterbauer; Klaus Lechner; Klaus Geissler; Leopold Ohler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of hematology     Volume:  78     ISSN:  0925-5710     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-11-07     Completed Date:  2004-02-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  241-7     Citation Subset:  IM    
Department of Internal Medicine I, Division of Hematology, University of Vienna, Austria.
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MeSH Terms
Acute Disease
Aged, 80 and over
Cell Division
Colony-Forming Units Assay
Cytogenetic Analysis
Leukemia, Myeloid / genetics*,  mortality,  pathology*
Middle Aged
Predictive Value of Tests
Prospective Studies
Remission Induction
Survival Analysis
Treatment Outcome
Tumor Cells, Cultured

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