| Relation of in vitro growth characteristics to cytogenetics and treatment outcome in acute myeloid leukemia: prognostic significance in patients with a normal karyotype. | |
| | |
MedLine Citation:
|
PMID: 14604283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We analyzed in vitro growth characteristics of bone marrow mononuclear cells (BMMCs) from 322 patients with acute myeloid leukemia (AML) in relation to cytogenetic abnormalities. Median colony growth was low in each of the cytogenetic changes associated with a favorable outcome. Most karyotypic abnormalities in the intermediate prognosis group were associated with low growth potential, but 11 q23 abnormalities exhibited 8 times higher in vitro growth. Cytogenetic changes that included abn(3q) seemed to display the highest colony growth in the unfavorable prognosis group, whereas isolated -7 may have been associated with limited growth potential. In vitro growth behavior was predictive of neither rate of complete remission (CR) nor survival of AML patients within the 3 cytogenetic risk groups. In contrast, colony growth differed significantly in the subgroup of patients with a normal karyotype who achieved remission with induction treatment and those who had no remission (10 versus 81.5/10(5) BMMCs; P = .015). Significantly more patients with normal cytogenetics and colony growth below the 50th percentile went into CR than did patients with colony growth above the 50th percentile (82.8% versus 71.2%). Only 4 (6.8%) of the patients in the low growth group had no remission, compared with 12 (23.1%) of the patients with higher in vitro growth (P = .031, chi-square test). In conclusion, colony growth may prove useful as a prognostic factor for early treatment failure in AML patients with a normal karyotype. |
| | |
Authors:
|
Andrea Berer; Birgit Kainz; Ulrich Jäger; Eva Jäger; Susanna Stengg; Berthold Streubel; Christa Fonatsch; Gerlinde Mitterbauer; Klaus Lechner; Klaus Geissler; Leopold Ohler |
Related Documents
:
|
11290893 - Detection of minimal residual disease in acute leukemia by tc-99m mibi femoral marrow i... 275533 - Blastic transformation in chronic myelogenous leukemia: experience with 50 patients. 3779533 - The value of prolonged electroencephalographic and video monitoring in diagnosis of sei... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International journal of hematology Volume: 78 ISSN: 0925-5710 ISO Abbreviation: Int. J. Hematol. Publication Date: 2003 Oct |
Date Detail:
|
Created Date: 2003-11-07 Completed Date: 2004-02-20 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9111627 Medline TA: Int J Hematol Country: Ireland |
Other Details:
|
Languages: eng Pagination: 241-7 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine I, Division of Hematology, University of Vienna, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Adolescent Adult Aged Aged, 80 and over Cell Division Colony-Forming Units Assay Cytogenetic Analysis Humans Leukemia, Myeloid / genetics*, mortality, pathology* Middle Aged Predictive Value of Tests Prognosis Prospective Studies Remission Induction Survival Analysis Treatment Outcome Tumor Cells, Cultured |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of the tyrosine kinase inhibitor imatinib mesylate on a Bcr-Abl-positive cell line: suppress...
Next Document: L-asparaginase-Based induction therapy for advanced extranodal NK/T-cell lymphoma.