| Relation of high-density lipoprotein cholesterol to mortality after percutaneous coronary interventions in patients with low-density lipoprotein <70 mg/dl. | |
| | |
MedLine Citation:
|
PMID: 19166688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
High-density lipoprotein (HDL) cholesterol level is a strong predictor of morbidity and mortality in the general population. Conflicting data exist on the protective effects of high HDL cholesterol in patients with optimal low-density lipoprotein (LDL) cholesterol levels. To determine the association of high HDL cholesterol with mortality in patients with LDL cholesterol levels <70 mg/dl who undergo percutaneous coronary intervention, 3,616 consecutive patients with LDL cholesterol levels <70 mg/dl who underwent percutaneous coronary intervention from July 1, 1999, to June 1, 2007, were retrospectively analyzed and followed through July 1, 2007. All-cause mortality was identified using the National Death Index. The mortality rates was 34.7, 25.2, 23.7, and 18.8 per 1,000 person-years in patients with HDL cholesterol levels of <40, 40 to 49, 50 to 59, and > or =60 mg/dl, respectively (p for trend <0.001). After multivariate adjustment for demographic characteristics, cigarette smoking, biochemical variables, and co-morbid conditions, the hazard ratios for mortality in patients with HDL cholesterol levels of 40 to 49, 50 to 59, and > or =60 mg/dl, compared with their counterparts with HDL cholesterol levels <40 mg/dl, were 0.68 (95% confidence interval [CI] 0.50 to 0.93), 0.55 (95% CI 0.35 to 0.85), and 0.45 (95% CI 0.27 to 0.74), respectively. For each 1-SD increase in HDL cholesterol level (14 mg/dl), the multivariate-adjusted hazard ratio for all-cause mortality was 0.68 (95% CI 0.58 to 0.79). In conclusion, in patients with LDL cholesterol levels <70 mg/dl who underwent percutaneous coronary intervention, a strong inverse association was present between HDL cholesterol level and all-cause mortality. |
| | |
Authors:
|
Annapoorna S Kini; Paul Muntner; Pedro R Moreno; Devin Mann; Prakash Krishnan; Michael C Kim; Oana C Rafael; Michael E Farkouh; Samin K Sharma |
Related Documents
:
|
18418538 - The effects of zoledronic acid on serum lipids in multiple myeloma patients. 16310198 - Ldl-cholesterol lowering or hdl-cholesterol raising for cardiovascular prevention. a le... 11748098 - Influence of low high-density lipoprotein cholesterol and elevated triglyceride on coro... 8350608 - The effects of a walking program on body composition and serum lipids and lipoproteins ... 15657738 - Dynamics of blood chylomicron fatty acids in a marine carnivore: implications for lipid... 7315768 - Selenium balance in young men during selenium depletion and repletion. |
Publication Detail:
|
Type: Journal Article Date: 2008-11-19 |
Journal Detail:
|
Title: The American journal of cardiology Volume: 103 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2009 Feb |
Date Detail:
|
Created Date: 2009-01-26 Completed Date: 2009-02-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 350-4 Citation Subset: AIM; IM |
Affiliation:
|
Cardiac Catheterization Laboratory of the Cardiovascular Institute, Mount Sinai Hospital, New York, NY, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Angioplasty, Transluminal, Percutaneous Coronary / mortality* Cause of Death Cholesterol, HDL / blood* Cholesterol, LDL / blood* Female Humans Male Middle Aged Proportional Hazards Models |
| Chemical | |
Reg. No./Substance:
|
0/Cholesterol, HDL; 0/Cholesterol, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of the sirolimus-eluting versus paclitaxel-eluting coronary stent in patients with diabet...
Next Document: Impact of left ventricular dysfunction on hospital mortality among patients undergoing elective perc...