Document Detail

Relation of high cytomegalovirus antibody titres to blood pressure and brachial artery flow-mediated dilation in young men: the Cardiovascular Risk in Young Finns Study.
MedLine Citation:
PMID:  22236008     Owner:  NLM     Status:  MEDLINE    
Human cytomegalovirus (CMV) infection is associated with a higher risk of cardiovascular disease in immunocompromised organ transplant patients. It has been linked with the pathogenesis of elevated arterial blood pressure. However, controversy exists as to whether CMV infection is associated with endothelial function, and little is known about its role as a potential risk factor for early atherosclerosis development at a young age. We aimed to discover if CMV antibody titres are associated with early vascular changes (carotid intima-media thickness, carotid artery distensibility and brachial artery flow-mediated dilation), blood pressure elevation or other traditional cardiovascular risk factors. CMV antibody titres were measured in 1074 women and 857 men (aged 24-39 years) taking part in the Cardiovascular Risk in Young Finns study. CMV antibody titres were significantly higher in women compared to men. In men, high CMV antibody titres were associated directly with age (P < 0·001) and systolic (P = 0·053) and diastolic (P = 0·002) blood pressure elevation, and associated inversely with flow-mediated dilation (P = 0·014). In women, CMV antibody titres did not associate with any of the analysed parameters. In a multivariate regression model, which included traditional atherosclerotic risk factors, CMV antibody titres were independent determinants for systolic (P = 0·029) and diastolic (P = 0·004) blood pressure elevation and flow-mediated dilation (P = 0·014) in men. High CMV antibody titres are associated independently with blood pressure and brachial artery flow-mediated dilation in young men. This association supports the hypothesis that common CMV infection and/or an immune response to CMV may lead to impaired vascular function at a young age.
A Haarala; M Kähönen; T Lehtimäki; J Aittoniemi; J Jylhävä; N Hutri-Kähönen; L Taittonen; T Laitinen; M Juonala; J Viikari; O T Raitakari; M Hurme
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  167     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-12     Completed Date:  2012-03-05     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  309-16     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology.
Department of Microbiology and Immunology, University of Tampere, Medical School, Tampere, Finland.
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MeSH Terms
Antibodies, Viral / blood*
Blood Glucose / analysis
Blood Pressure*
Brachial Artery / physiopathology*
C-Reactive Protein / analysis
Cardiovascular Diseases / epidemiology*
Carotid Arteries / ultrasonography
Cytomegalovirus / immunology*
Cytomegalovirus Infections / blood,  epidemiology,  immunology,  physiopathology*
Finland / epidemiology
Follow-Up Studies
Hypertension / epidemiology,  etiology
Lipids / blood
Risk Factors
Sampling Studies
Seroepidemiologic Studies
Reg. No./Substance:
0/Antibodies, Viral; 0/Blood Glucose; 0/Lipids; 9007-41-4/C-Reactive Protein

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