Document Detail

Relation of endocrine and cardiac findings in acromegalics.
MedLine Citation:
PMID:  1532809     Owner:  NLM     Status:  MEDLINE    
Cardiac involvement in 32 acromegalics was related to endocrine parameters, clinical score and duration of the disease as well as compared to that of 50 controls free of cardiac disease. Stress ECG, 24h Holter monitoring and echocardiography revealed that supraventricular premature complexes did not occur more often in acromegalics than in controls, both prevalence and severity of ventricular arrhythmia, however, were higher in patients compared to controls: 15/32 (48%) acromegalics had complex ventricular arrhythmia as compared with 6/50 (12%) normal subjects (p less than 0.01). Repetitive ventricular arrhythmia was manifest in 10/32 (31%) patients but only in 4/50 (8%) controls (p less than 0.01). Furthermore, frequency of ventricular premature complexes increased with duration of acromegaly (p less than 0.01), the severity of the former being correlated with left ventricular mass and with clinical activity score (p less than 0.01). No correlation, however, was found between the degree of ventricular arrhythmia and hormone levels. Left ventricular muscle mass was increased (p less than 0.02) due to concentric hypertrophy. Thus, compared to controls, acromegalics show more frequent and complex ventricular arrhythmia and left ventricular hypertrophy. Duration of the disease rather than hormone levels seems to be relevant for these pathological changes.
G Kahaly; C Stover; J Beyer; S Mohr-Kahaly
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  15     ISSN:  0391-4097     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-05-14     Completed Date:  1992-05-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  13-8     Citation Subset:  IM    
III, Department of Medicine, Johannes Gutenberg University Hospital, Mainz, FRG.
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MeSH Terms
Acromegaly / blood*,  complications*
Arrhythmias, Cardiac / complications*,  epidemiology
Cardiomegaly / complications*
Circadian Rhythm / physiology
Growth Hormone / blood*
Middle Aged
Severity of Illness Index
Reg. No./Substance:
9002-72-6/Growth Hormone

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