Document Detail

Relation of diurnal blood pressure variation and triglyceride-to-high-density lipoprotein cholesterol ratio in patients without diabetes mellitus.
MedLine Citation:
PMID:  15619409     Owner:  NLM     Status:  MEDLINE    
A night-time decrease in systolic blood pressure that differs <10% from mean daytime values ("nondipping") is associated with increased rates of cardiovascular morbidity and mortality. We hypothesized that insulin resistance would be associated with nondipping in patients who did not have frank diabetes mellitus or hypertension. We included 106 consecutive outpatients who had been referred for 24-hour ambulatory monitoring of blood pressure. Our data suggest that insulin resistance, defined as a high ratio of triglyceride to high-density lipoprotein, is associated with blunted diurnal blood pressure variation (odds ratio 6.3, 95% confidence interval 2.6 to 16.4, p <0.0001) before the development of abnormal levels of fasting blood glucose.
Michael B Davidson; Donald G Vidt; Byron J Hoogwerf; Daniel J Brotman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  95     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-27     Completed Date:  2005-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  123-6     Citation Subset:  AIM; IM    
Department of General Internal Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
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MeSH Terms
Blood Pressure / physiology*
Cholesterol, HDL / blood*
Circadian Rhythm*
Cross-Sectional Studies
Diabetes Mellitus
Insulin Resistance*
Middle Aged
Triglycerides / blood*
Reg. No./Substance:
0/Cholesterol, HDL; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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