| Relation of distortion product otoacoustic emission with tinnitus. | |
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MedLine Citation:
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PMID: 18176342 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate cochlear outer hair cell function based on distortion product otoacoustic emission (DPOAE) in patients with tinnitus. STUDY DESIGN: This is a case control study. SUBJECTS AND METHODS: The subjects are patients who attended the Otorhinolaryngology Clinic in Hospital Universiti Kebangsaan Malaysia over a period of 19 months from April 2005 until October 2006. All patients underwent a full ENT assessment and had tympanometry, pure tone audiometry, and DPOAE tests. The UKM Research and Ethics Committee reviewed and approved the study proposal prior to commencement of this study. RESULTS: The study population included 49 patients. They consisted of 16 patients (32 ears) with tinnitus and reduced hearing, 13 patients (26 ears) with tinnitus and normal hearing, 7 patients (13 ears) without tinnitus with reduced hearing, and 13 patients (26 ears) without tinnitus with normal hearing. Statistical analysis showed significant differences (P = .00) of mean DPOAE levels between the four groups of patients. CONCLUSION: Our results suggest that reduced outer hair cell activity, as detected by reduced DPOAE levels, may manifest as tinnitus even before there is a shift on hearing threshold. We also postulate that further reduction of cochlear outer hair cell activity, as shown by further reduced DPOAE levels, may actually terminate the source of tinnitus. |
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Authors:
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Mazita Ami; Asma Abdullah; Mahamad A Awang; Borhan Liyab; Lokman Saim |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Laryngoscope Volume: 118 ISSN: 0023-852X ISO Abbreviation: Laryngoscope Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-31 Completed Date: 2008-06-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607378 Medline TA: Laryngoscope Country: United States |
Other Details:
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Languages: eng Pagination: 712-7 Citation Subset: IM |
Affiliation:
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Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine. Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. mazitaami@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Impedance Tests Adult Aged Audiometry, Pure-Tone Auditory Perception / physiology* Auditory Threshold / physiology* Bone Conduction / physiology Case-Control Studies Chronic Disease Cochlea / physiopathology* Evoked Potentials, Auditory / physiology Female Hair Cells, Auditory, Outer / physiology* Hearing / physiology Hearing Loss / physiopathology Humans Male Middle Aged Tinnitus / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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