Document Detail

Relation of distortion product otoacoustic emission with tinnitus.
MedLine Citation:
PMID:  18176342     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate cochlear outer hair cell function based on distortion product otoacoustic emission (DPOAE) in patients with tinnitus. STUDY DESIGN: This is a case control study. SUBJECTS AND METHODS: The subjects are patients who attended the Otorhinolaryngology Clinic in Hospital Universiti Kebangsaan Malaysia over a period of 19 months from April 2005 until October 2006. All patients underwent a full ENT assessment and had tympanometry, pure tone audiometry, and DPOAE tests. The UKM Research and Ethics Committee reviewed and approved the study proposal prior to commencement of this study. RESULTS: The study population included 49 patients. They consisted of 16 patients (32 ears) with tinnitus and reduced hearing, 13 patients (26 ears) with tinnitus and normal hearing, 7 patients (13 ears) without tinnitus with reduced hearing, and 13 patients (26 ears) without tinnitus with normal hearing. Statistical analysis showed significant differences (P = .00) of mean DPOAE levels between the four groups of patients. CONCLUSION: Our results suggest that reduced outer hair cell activity, as detected by reduced DPOAE levels, may manifest as tinnitus even before there is a shift on hearing threshold. We also postulate that further reduction of cochlear outer hair cell activity, as shown by further reduced DPOAE levels, may actually terminate the source of tinnitus.
Mazita Ami; Asma Abdullah; Mahamad A Awang; Borhan Liyab; Lokman Saim
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Laryngoscope     Volume:  118     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-31     Completed Date:  2008-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  712-7     Citation Subset:  IM    
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine. Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
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MeSH Terms
Acoustic Impedance Tests
Audiometry, Pure-Tone
Auditory Perception / physiology*
Auditory Threshold / physiology*
Bone Conduction / physiology
Case-Control Studies
Chronic Disease
Cochlea / physiopathology*
Evoked Potentials, Auditory / physiology
Hair Cells, Auditory, Outer / physiology*
Hearing / physiology
Hearing Loss / physiopathology
Middle Aged
Tinnitus / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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