Document Detail

Relation of degree of physical activity to coronary artery calcium score in asymptomatic individuals with multiple metabolic risk factors.
MedLine Citation:
PMID:  15374775     Owner:  NLM     Status:  MEDLINE    
Lack of physical activity (PA) increases risk of coronary heart disease. Metabolic risk factors increase the risk of coronary heart disease and development of advanced coronary artery calcium (CAC). We hypothesized that, in a population with multiple metabolic risk factors (> or =2), the degree of PA would be inversely associated with the degree and prevalence of CAC. After excluding subjects who had known diabetes and coronary heart disease, we studied 779 asymptomatic patients referred for electron beam tomography. All patients had > or =2 of the following metabolic risk factors: blood pressure > 130/85 mm Hg, serum triglycerides >150 mg/dl, serum high-density lipoprotein < 40 and < 50 mg/dl in men and women, respectively, and body mass index >30 kg/m(2). Advanced CAC was defined as a calcium score >75th percentile based on gender and age. In the study, 37% patients were sedentary, 26% engaged in moderate-duration (< 30 minutes 1 to 2 times/week) PA, and 37% engaged in long-duration (> or =30 minutes > or =3 times/week) PA. The median CAC scores were 24 (sedentary), 18 (moderate PA), and 11 (long-duration PA; p <0.002). Advanced CAC was prevalent in 26% of sedentary patients, 24% of patients who performed moderate PA, and 16% of patients who engaged in long-duration PA (p <0.05). On logistic regression analysis, long-duration PA had an independent inverse association with advanced CAC. Thus, asymptomatic patients who have > or =2 metabolic risk factors and who regularly engage in long-duration PA have a lower prevalence of CAC than do those who are sedentary or participate in moderate-duration PA.
Milind Y Desai; Khurram Nasir; John A Rumberger; Joel B Braunstein; Wendy S Post; Matthew J Budoff; Roger S Blumenthal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  94     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-17     Completed Date:  2004-11-02     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  729-32     Citation Subset:  AIM; IM    
Ciccarone Preventive Cardiology Center, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
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MeSH Terms
Calcinosis / complications*,  epidemiology,  radiography
Chi-Square Distribution
Coronary Artery Disease / complications*,  epidemiology,  radiography
Cross-Sectional Studies
Lipids / blood
Logistic Models
Metabolic Syndrome X / complications*,  epidemiology,  radiography
Physical Fitness*
Risk Factors
Statistics, Nonparametric
Tomography, X-Ray Computed
Reg. No./Substance:

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