| Relation of cytogenetic abnormalities and clinical outcome in metastatic melanoma. | |
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MedLine Citation:
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PMID: 2336077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The value of chromosomal analysis is well established in human hematologic neoplasms. In contrast, the relation between chromosomal abnormalities and clinical outcome in solid tumors in humans has received little study. We undertook this study to determine whether chromosomal abnormalities could provide information on the survival of patients with malignant melanoma. Chromosome-banding analysis was performed on tumor-biopsy samples from 62 patients with metastatic melanoma, and recurring cytogenetic abnormalities were correlated with survival. Patients with structural abnormalities of chromosome 7 or 11 had significantly shorter survival than patients without these abnormalities. We conclude that cytogenetic analysis may provide useful prognostic information about patients with metastatic melanoma. |
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Authors:
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J M Trent; F L Meyskens; S E Salmon; K Ryschon; S P Leong; J R Davis; D L McGee |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The New England journal of medicine Volume: 322 ISSN: 0028-4793 ISO Abbreviation: N. Engl. J. Med. Publication Date: 1990 May |
Date Detail:
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Created Date: 1990-06-11 Completed Date: 1990-06-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1508-11 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Arizona, Tucson 85724. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromosome Aberrations* Chromosome Banding Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 11* Chromosomes, Human, Pair 6 Chromosomes, Human, Pair 7* Female Humans Male Melanoma / diagnosis, genetics*, mortality Middle Aged Neoplasm Metastasis Neoplasm Staging Prognosis Survival Analysis |
| Grant Support | |
ID/Acronym/Agency:
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CA-23074/CA/NCI NIH HHS; CA-29476/CA/NCI NIH HHS; CA-41183/CA/NCI NIH HHS |
| Comments/Corrections | |
Comment In:
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N Engl J Med. 1990 Nov 1;323(18):1283
[PMID:
2215612
]
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Erratum In:
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N Engl J Med 1990 Nov 1;323(18):1283 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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