Document Detail

Relation of coronary vasoreactivity and coronary calcification in asymptomatic subjects with a family history of premature coronary artery disease.
MedLine Citation:
PMID:  14740179     Owner:  NLM     Status:  MEDLINE    
Electron-beam computed tomography (EBCT) allows non-invasive imaging of coronary calcification and has been promoted as a screening tool for coronary artery disease (CAD) in asymptomatic high-risk subjects. This study assessed the relation of coronary calcifications to alterations in coronary vascular reactivity by means of positron emission tomography (PET) in asymptomatic subjects with a familial history of premature CAD. Twenty-one subjects (mean age 51+/-10 years) underwent EBCT imaging for coronary calcifications expressed as the coronary calcium score (CCS according to Agatston) and rest/adenosine-stress nitrogen-13 ammonia PET with quantification of myocardial blood flow (MBF) and coronary flow reserve (CFR). The mean CCS was 237+/-256 (median 146, range 0-915). The CCS was <100 in eight subjects and >100 units in 13. As defined by age-related thresholds, 15 subjects had an increased CCS (>75th percentile). Overall mean resting and stress MBF and CFR were 71+/-16 ml 100 g(-1) min(-1), 218+/-54 ml 100 g(-1) min(-1) and 3.20+/-0.77, respectively. Three subjects with CCS ranging from 114 to 451 units had an abnormal CFR (<2.5). There was no relation between CCS and resting or stress MBF or CFR ( r=0.17, 0.18 and 0.10, respectively). In asymptomatic subjects a pathological CCS was five times more prevalent than an abnormal CFR. The absence of any close relationship between CCS and CFR reflects the fact that quantitative myocardial perfusion imaging with PET characterises the dynamic process of vascular reactivity while EBCT is a measure of more stable calcified lesions in the arterial wall whose presence is closely related to age.
Christian Pirich; Alexander Leber; Andreas Knez; Frank M Bengel; Stephan G Nekolla; Ralph Haberl; Markus Schwaiger
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-01-22
Journal Detail:
Title:  European journal of nuclear medicine and molecular imaging     Volume:  31     ISSN:  1619-7070     ISO Abbreviation:  Eur. J. Nucl. Med. Mol. Imaging     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-12-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101140988     Medline TA:  Eur J Nucl Med Mol Imaging     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  663-70     Citation Subset:  IM    
Nuklearmedizinische Klinik und Poliklinik der Technischen Universität München, Germany.
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MeSH Terms
Age Factors
Calcinosis / complications,  radionuclide imaging*
Cardiomyopathy, Dilated / epidemiology*,  radionuclide imaging*
Coronary Artery Disease / epidemiology*,  radionuclide imaging*
Coronary Vessels / radionuclide imaging*
Genetic Predisposition to Disease / epidemiology
Germany / epidemiology
Middle Aged
Positron-Emission Tomography / methods
Risk Assessment / methods*
Risk Factors
Statistics as Topic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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