Document Detail

Relation of contractile reserve during low-dose dobutamine echocardiography and angiographic extent and severity of coronary artery disease in the presence of left ventricular dysfunction.
MedLine Citation:
PMID:  9165148     Owner:  NLM     Status:  MEDLINE    
Contractile reserve, during low-dose dobutamine echocardiography, is frequently used for the assessment of myocardial viability in patients with coronary artery disease (CAD) and left ventricular (LV) dysfunction. Whether contractile reserve is affected by the severity of the underlying CAD is presently unknown. Accordingly, we studied 58 patients with stable CAD and LV dysfunction who underwent coronary angiography and low-dose dobutamine echocardiography. In each vascular region the worst stenosis was identified and quantitated as percent diameter stenosis. Segmental wall motion during echocardiography was scored visually and rest and dobutamine wall motion score indexes were calculated. Contractile reserve was defined as > or = 1 grade improvement in wall motion score of > or = 2 contiguous segments along with > or = 20% reduction in global wall motion score index with dobutamine. There was no difference between patients with (n = 26) and without (n = 32) contractile reserve in percent coronary stenosis (89 +/- 17% vs 87 +/- 17%, p = 0.6), number of coronary arteries with > 50% diameter stenosis (2.0 +/- 0.8 vs 2.2 +/- 0.7, p = 0.4), number of occluded coronary arteries (1.2 +/- 0.9 vs 1.1 +/- 0.9, p = 0.6), or the prevalence of collaterals demonstrated angiographically (61% vs 56%, p = 0.5). Our data demonstrates that in patients with CAD and LV dysfunction, the prevalence of contractile reserve during low-dose dobutamine echocardiography is independent of the angiographic extent and severity of CAD.
M L Main; P A Grayburn; C Landau; I Afridi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  79     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-19     Completed Date:  1997-06-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1309-13     Citation Subset:  AIM; IM    
Department of Medicine, University of Texas Southwestern and Veterans Administration Medical Centers, Dallas 75216, USA.
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MeSH Terms
Cardiotonic Agents / administration & dosage,  diagnostic use*
Coronary Angiography
Coronary Disease / physiopathology*,  radiography,  ultrasonography*
Dobutamine / administration & dosage,  diagnostic use*
Middle Aged
Myocardial Contraction*
Prospective Studies
Retrospective Studies
Ventricular Dysfunction, Left / physiopathology*,  radiography
Reg. No./Substance:
0/Cardiotonic Agents; 34368-04-2/Dobutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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