| Relation of changes over time in ventricular size and function to those in exercise capacity in patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 10783227 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We studied the direction and magnitude of changes in left ventricular (LV) cavity size and mass over time and whether these changes were related to those in exercise performance in patients with chronic heart failure (CHF). METHODS AND RESULTS: The study group was composed of 59 patients (55 men aged 58 +/- 10 years) with CHF and LV end-diastolic diameter (EDD) >55 mm. All underwent echocardiography and a treadmill cardiopulmonary exercise test within a 4-week interval (baseline) and again after a period of >/=4 months (median of 14 months). At baseline, the group as a whole had moderate to severe LV dysfunction with an EDD of 70 +/- 9 mm, end-systolic diameter (ESD) of 60 +/- 11 mm, and LV mass of 500 +/- 200 g. The mean peak oxygen consumption (Vo (2), 18 +/- 6 mL/kg per minute) was unrelated to LV cavity size or mass. EDD increased in 37 (63%) of the patients and fell in 22 (37%) patients from the initial to the second test. The absolute magnitude of changes over time averaged 7 mm for EDD, 125 g for mass, and 6 mL/kg per minute for peak Vo(2). Changes in LV size and mass per year were significantly related to those in peak Vo(2) (r = -0.49 for EDD, r = -0.56 for ESD, and r = -0.44 for LV mass, respectively, all P <.001) and ventilatory response to exercise (r = 0.60, r = 0.58, and r = 0.72 for EDD, ESD, and LV mass; respectively, all P <.001). CONCLUSIONS: Changes over time in objective measures of LV dimensions and mass, in patients with CHF are significantly related to those in exercise capacity and respiratory efficiency. |
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Authors:
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V G Florea; M Y Henein; S D Anker; D P Francis; D G Gibson; A J Coats |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American heart journal Volume: 139 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-05-30 Completed Date: 2000-05-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 913-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom. vioflor@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Exercise Test* Female Follow-Up Studies Heart Failure / diagnosis*, physiopathology Humans Hypertrophy, Left Ventricular / diagnosis*, physiopathology Male Middle Aged Pulmonary Gas Exchange / physiology Retrospective Studies Stroke Volume / physiology Ventricular Dysfunction, Left / diagnosis*, physiopathology Ventricular Function, Left / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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