Document Detail

Relation of central alpha-adrenoceptor and other receptors to the control of renin secretion.
MedLine Citation:
PMID:  6129946     Owner:  NLM     Status:  MEDLINE    
The location and nature of the receptors in the brain on which clonidine acts to decrease renin secretion have been investigated in dogs. Clonidine was injected into the vertebral and carotid arteries, and its effects were compared with those of norepinephrine and epinephrine when injected into the third ventricle. It was also injected intravenously (IV) after transection of the brain stem and following treatment with intraventricular 6-hydroxydopamine. The results suggest that the renin-regulating receptors are located in the brain stem in a region different from the receptors mediating the depressor response, that they are alpha 2-adrenoceptors, and that they are postsynaptic in location. Central alpha 1-adrenoceptors appear to mediate increased renin secretion. Central serotonergic receptors also mediate increased renin secretion, but it is not known how the alpha 1- and alpha 2-adrenoceptors interact with the serotonergic systems.
W F Ganong
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chest     Volume:  83     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-03-24     Completed Date:  1983-03-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  299-302     Citation Subset:  AIM; IM; S    
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology
Blood Pressure / drug effects
Brain Stem / physiology*
Clonidine / pharmacology
Epinephrine / pharmacology
Hydroxydopamines / pharmacology
Norepinephrine / pharmacology
Receptors, Adrenergic / physiology*
Receptors, Adrenergic, alpha / drug effects,  physiology*
Receptors, Serotonin / physiology
Renin / secretion*
Yohimbine / pharmacology
Grant Support
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Hydroxydopamines; 0/Receptors, Adrenergic; 0/Receptors, Adrenergic, alpha; 0/Receptors, Serotonin; 146-48-5/Yohimbine; 4205-90-7/Clonidine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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