Document Detail


Relation of cardiovascular risk factors to right ventricular structure and function as determined by magnetic resonance imaging (results from the multi-ethnic study of atherosclerosis).
MedLine Citation:
PMID:  20609657     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of cardiovascular risk factors on the left ventricle is well known but their effect on right ventricle has not been studied using advanced imaging techniques. The purpose of the present study was to determine the relation between the cardiovascular risk factors and right ventricular (RV) structure and function and its interaction with the left ventricle. Cardiac magnetic resonance images from 4,204 participants free of clinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis were analyzed. Multivariate linear regression models were used to study the cross-sectional association between individual RV parameters and risk factors. All RV parameters, except for ejection fraction, decreased with age (p <0.0001). The RV mass was positively associated with systolic blood pressure (+0.4 g, p <0.0001) and high-density lipoprotein cholesterol (+0.2 g, p <0.0001). It was inversely related with diastolic blood pressure (-0.3 g, p <0.0001) and total cholesterol (-0.2 g, p <0.01). The RV end-diastolic volume was positively associated with systolic blood pressure (+1.6 ml, p <0.01) and high-density lipoprotein cholesterol (+1.8 ml, p <0.0001). It was inversely related with diastolic blood pressure (-2.2 ml, p <0.01), total cholesterol (-1.4 ml, p <0.0001), current smoking (-2.7 ml, p <0.05), and diabetes mellitus (-3.1 ml, p <0.01). The RV ejection fraction was positively associated with systolic blood pressure (+1.0%, p <0.0001), high-density lipoprotein cholesterol (+0.4%, p <0.0001) and inversely with diastolic blood pressure (-0.7%, p <0.0001). In conclusion, the mass and volumes of the right ventricle decrease with age. Cardiovascular risk factors, especially blood pressure and high-density lipoprotein cholesterol, are associated with subclinical changes in the RV mass and volume.
Authors:
Harjit Chahal; Craig Johnson; Harikrishna Tandri; Aditya Jain; W Gregory Hundley; R Graham Barr; Steven M Kawut; Joao A C Lima; David A Bluemke
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2010-05-13
Journal Detail:
Title:  The American journal of cardiology     Volume:  106     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-09-14     Revised Date:  2014-10-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  110-6     Citation Subset:  AIM; IM    
Copyright Information:
Copyright (c) 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aged
Female
Heart Ventricles / physiopathology*
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Organ Size
Risk Assessment
Risk Factors
Ventricular Dysfunction, Right / diagnosis*,  physiopathology
Ventricular Function / physiology*
Grant Support
ID/Acronym/Agency:
N01 HC095159/HC/NHLBI NIH HHS; N01 HC095160/HC/NHLBI NIH HHS; N01 HC095161/HC/NHLBI NIH HHS; N01 HC095162/HC/NHLBI NIH HHS; N01 HC095163/HC/NHLBI NIH HHS; N01 HC095164/HC/NHLBI NIH HHS; N01 HC095165/HC/NHLBI NIH HHS; N01 HC095166/HC/NHLBI NIH HHS; N01 HC095167/HC/NHLBI NIH HHS; N01 HC095168/HC/NHLBI NIH HHS; N01 HC095169/HC/NHLBI NIH HHS; N01-HC-95159/HC/NHLBI NIH HHS; N01-HC-95160/HC/NHLBI NIH HHS; N01-HC-95161/HC/NHLBI NIH HHS; N01-HC-95162/HC/NHLBI NIH HHS; N01-HC-95163/HC/NHLBI NIH HHS; N01-HC-95164/HC/NHLBI NIH HHS; N01-HC-95165/HC/NHLBI NIH HHS; N01-HC-95166/HC/NHLBI NIH HHS; N01-HC-95167/HC/NHLBI NIH HHS; N01-HC-95168/HC/NHLBI NIH HHS; N01-HC-95169/HC/NHLBI NIH HHS; R01 HL077612/HL/NHLBI NIH HHS; R01 HL086719/HL/NHLBI NIH HHS; R01 HL086719/HL/NHLBI NIH HHS; R01 HL086719-01/HL/NHLBI NIH HHS; Z99 CL999999/CL/CLC NIH HHS; ZIA CL090019-01/CL/CLC NIH HHS; ZIA EB000072-01/EB/NIBIB NIH HHS
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