Document Detail

Relation between visceral fat and coronary artery disease evaluated by multidetector computed tomography.
MedLine Citation:
PMID:  19922936     Owner:  NLM     Status:  MEDLINE    
Visceral abdominal fat has been associated to cardiovascular risk factors and coronary artery disease (CAD). Computed tomography (CT) coronary angiography is an emerging technology allowing detection of both obstructive and nonobstructive CAD adding information to clinical risk stratification. The aim of this study was to evaluate the association between CAD and adiposity measurements assessed clinically and by CT. We prospectively evaluated 125 consecutive subjects (57% men, age 56.0+/-12 years) referred to perform CT angiography. Clinical and laboratory variables were determined and CT angiography and abdominal CT were performed in a 64-slice scanner. CAD was defined as any plaque calcified or not detected by CT angiography. Visceral and subcutaneous adiposity areas were determined at different intervertebral levels. CT angiography detected CAD in 70 (56%) subjects, and no association was found with usual anthropometric adiposity measurements (waist and hip circumferences and body mass index). Otherwise, CT visceral fat areas (VFA) were significantly related to CAD. VFA T12-L1 values > or =145cm(2) had an odds ratio of 2.85 (95% CI 1.30-6.26) and VFA L4-L5 > or =150cm(2) had a 2.87-fold (95% CI 1.31-6.30) CAD risk. The multivariate analysis determined age and VFA T12-L1 as the only independent variables associated to CAD. Visceral fat assessed by CT is an independent marker of CAD determined by CT angiography.
Mateus D Marques; Raul D Santos; Jose R Parga; Jose A Rocha-Filho; Luiz A Quaglia; Marcio H Miname; Luiz F Avila
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-29
Journal Detail:
Title:  Atherosclerosis     Volume:  209     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-26     Completed Date:  2010-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  481-6     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Heart Institute (InCor) University of Sao Paulo Medical School, Brazil.
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MeSH Terms
Aged, 80 and over
Calcinosis / complications
Coronary Angiography / methods
Coronary Artery Disease / etiology,  radiography*
Intra-Abdominal Fat / radiography*
Middle Aged
Multivariate Analysis
Obesity / complications*,  radiography
Risk Factors
Tomography, X-Ray Computed / methods

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