Document Detail

Relation between upregulation of CD40 system and complex stenosis morphology in patients with acute coronary syndrome.
MedLine Citation:
PMID:  14769218     Owner:  NLM     Status:  MEDLINE    
AIM: To investigate whether upregulation of CD40-CD40 ligand system is related to matrix metalloproteinases level and stability of coronary atherosclerotic plaque in patients with acute coronary syndrome (ACS). METHODS: Sixteen normal controls and 56 patients including 24 with stable angina (SA), 20 with unstable angina (UA), and 12 with acute myocardial infarction (AMI) were investigated. The expression of CD40 and CD40L on platelet was analyzed by flow cytometry. Serum soluble CD40L (sCD40L), MMP-9 and MMP-3 level was determined by ELISA. All coronary stenosis with > or =30% diameter reduction were assessed by angiographic coronary stenosis morphology. RESULTS: Patients with ACS showed a significant increase of CD40 (75 +/- 12 MIF) and CD40L (13 +/- 4 MIF) coexpression on platelets compared with control and SA group (P<0.01). sCD40L also showed higher level in patients with ACS (10.2 +/- 3.5 microg/L) than in control (3.1 +/- 1.4 microg/L, P<0.01) and SA group (3.3 +/- 1.6 microg/L, P<0.01). Serum MMP-3 and MMP-9 in patients with ACS were two times greater than those in control. A positive correlation was found between MMP-9, MMP-3, and CD40L expression on platelets as well as sCD40L levels, but not for CD40 expression on platelets. An obvious correlation was also observed between sCD40L concentration and complex coronary stenoses (r=0.60, P<0.01). CONCLUSION: Patients with ACS show increased coexpression of CD40 system, especially expression of CD40L, which may create a proinflammatory and prothrombotic milieu for aggravating the development of atherosclerosis and instability of atherosclerotic plaques, and may be a valuable marker for predicting the severity of ACS.
Jin-chuan Yan; Zong-gui Wu; Xian-tao Kong; Ren-qian Zong; Lin-zen Zhan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pharmacologica Sinica     Volume:  25     ISSN:  1671-4083     ISO Abbreviation:  Acta Pharmacol. Sin.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-10     Completed Date:  2004-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100956087     Medline TA:  Acta Pharmacol Sin     Country:  China    
Other Details:
Languages:  eng     Pagination:  251-6     Citation Subset:  IM    
Department of Cardiology, Affiliated Zhong Da Hospital, Southeast University, Nanjing 210009, China.
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MeSH Terms
Angina Pectoris* / blood,  immunology,  pathology
Angina, Unstable* / blood,  immunology,  pathology
Antigens, CD40 / biosynthesis*
Blood Platelets / metabolism
CD40 Ligand / biosynthesis*
Matrix Metalloproteinase 3 / blood
Matrix Metalloproteinase 9 / blood
Middle Aged
Myocardial Infarction* / blood,  immunology,  pathology
Reg. No./Substance:
0/Antigens, CD40; 147205-72-9/CD40 Ligand; EC Metalloproteinase 3; EC Metalloproteinase 9

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