| Relation between stable isotope ratios in human red blood cells and hair: implications for using the nitrogen isotope ratio of hair as a biomarker of eicosapentaenoic acid and docosahexaenoic acid. | |
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MedLine Citation:
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PMID: 19864410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The nitrogen isotope ratio (expressed as delta(15)N) of red blood cells (RBCs) is highly correlated with the RBC long-chain omega-3 (n-3) fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in Yup'ik Eskimos. Because delta(15)N can also be measured in hair samples, it could provide a noninvasive, retrospective biomarker for EPA and DHA intakes. OBJECTIVES: We investigated the agreement between delta(15)N in hair and RBCs and then evaluated the relations between hair delta(15)N and RBC EPA and DHA. We also assessed the agreement in carbon isotope ratios (delta(13)C) between hair and RBCs, because delta(13)C has been proposed as a dietary biomarker in other populations. DESIGN: We assessed relations between hair and RBC delta(15)N and delta(13)C in a community-based sample of 144 Yup'ik Eskimos and examined the correlations between delta(15)N and RBC EPA and DHA in a subset of these participants (n = 44). RESULTS: We showed a 1:1 relation with good agreement between hair and RBC delta(15)N (r = 0.91) and delta(13)C (r = 0.87). Hair isotope ratios were greater than RBC ratios by 1.5 per thousand for delta(15)N and by 2.3 per thousand for delta(13)C. There were strong correlations between hair delta(15)N and RBC EPA and DHA (r = 0.83 and 0.84, respectively). CONCLUSIONS: These results support the use of hair delta(15)N values as a biomarker of EPA and DHA intakes. Because hair collection is noninvasive and the samples require no special processing, studies of EPA and DHA intakes in large populations could use biomarkers rather than self-reports to assess these fatty acids. |
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Authors:
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Sarah H Nash; Alan R Kristal; Bert B Boyer; Irena B King; Jordan S Metzgar; Diane M O'Brien |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-10-28 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 90 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-25 Completed Date: 2009-12-08 Revised Date: 2011-03-03 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1642-7 Citation Subset: AIM; IM |
Affiliation:
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Center for Alaska Native Health Research, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK 99775-7000, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Biological Markers Docosahexaenoic Acids / administration & dosage* Eicosapentaenoic Acid / administration & dosage* Erythrocytes / metabolism* Female Hair / metabolism* Humans Male Middle Aged Nitrogen Isotopes / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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P20 RR16430/RR/NCRR NIH HHS; R01DK07442/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Nitrogen Isotopes; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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