Document Detail


Relation between regular intake of phenacetin-containing analgesics and laboratory evidence for urorenal disorders in a working female population of Switzerland.
MedLine Citation:
PMID:  47016     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A study group of 623 employed Swiss women aged 30-49 years showing objective evidence of intake of phenacetin-containing analgesics, and a control group of 621 comparable women showing no such intake, were observed for 4 years (1969-72) for laboratory evidence of urorenal disorders. In both study and control groups morbidity was low. There was no difference between the study and control groups with respect to subsequent proteinuria, bacteriuria, and haematuria. The 4-year incidence of low urine specific gravity after overhight thirsting was significantly higher in the study group than in the control group (3-8% v. 0-8%) and the incidence of raised serum-creatinine was also significantly higher in the study group (2-9% v. 0-4%). However, when the study group was further subdivided into a sub-group showing evidence of high intake of phenacetincontaining analgesics and one showing low intake, only the high-intake subgroup had an incidence of raised serum-creatinine (5-4%) significantly higher than the control group (0-4%), whereas the low-intake subgroup had an incidence (0-4%) similar to the control group.
Authors:
U C Dubach; B Rosner; A Müller; P S Levy; H R Baumeler; A Peier; T Ehrensperger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1975 Mar 
Date Detail:
Created Date:  1975-05-27     Completed Date:  1975-05-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  539-43     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / urine
Adult
Age Factors
Bacteriuria / chemically induced*
Creatinine / blood
Female
Hematuria / chemically induced*,  epidemiology
Humans
Kidney Diseases / chemically induced*,  diagnosis,  epidemiology,  urine
Middle Aged
Occupational Medicine
Phenacetin / administration & dosage,  adverse effects*
Proteinuria / chemically induced*,  epidemiology
Sex Factors
Specific Gravity
Specimen Handling
Switzerland
Time Factors
Chemical
Reg. No./Substance:
103-90-2/Acetaminophen; 60-27-5/Creatinine; 62-44-2/Phenacetin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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