Document Detail

Relation between red blood cell distribution width (RDW) and all-cause mortality at two years in an unselected population referred for coronary angiography.
MedLine Citation:
PMID:  19144426     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Red blood cell distribution width (RDW), a numerical measure of the variability in size of circulating erythrocytes, has recently been shown to be a strong predictor of adverse outcomes in patients with heart failure and in patients with prior myocardial infarction but no symptomatic heart failure at baseline, even after adjustment for hematocrit. However, there are no data in other cardiac populations, including patients with acute coronary syndromes (ACS).
METHODS: The present study investigated the long-term prognostic significance of baseline RDW in a well-characterized cohort of 389 male patients who were referred to coronary angiography for a variety of indications. All patients were followed prospectively for all-cause mortality, and data regarding this endpoint was available for 97% of the population at 24 months.
RESULTS: After controlling for a variety of baseline variables (including hemoglobin and the presence of heart failure), RDW (analyzed as a categorical variable comparing the upper tertile of baseline values to the lower two levels combined) was a strong and independent predictor of all-cause mortality using a Cox proportional hazards model [hazard ratio (HR) 2.69, 95% confidence interval (CI) 1.50-4.84, p=0.0008]. In addition, baseline RDW was also an independent predictor of all-cause mortality in the non-anemic (HR 4.73, 95% CI 2.06-10.86, p=0.0003) and ACS (HR 2.90, 95% CI 1.32-6.38, p=0.0082) subpopulations of patients.
CONCLUSIONS: These data demonstrate that elevated RDW is a strong and independent predictor of all-cause mortality in an unselected population of male patients across a broad spectrum of risk (including ACS) referred for coronary angiography.
Erdal Cavusoglu; Vineet Chopra; Amit Gupta; Venkata R Battala; Shyam Poludasu; Calvin Eng; Jonathan D Marmur
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Publication Detail:
Type:  Journal Article     Date:  2009-01-13
Journal Detail:
Title:  International journal of cardiology     Volume:  141     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-21     Completed Date:  2010-09-14     Revised Date:  2010-12-21    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  141-6     Citation Subset:  IM    
Copyright Information:
Copyright 2008 Elsevier Ireland Ltd. All rights reserved.
Division of Cardiology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA.
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MeSH Terms
Acute Coronary Syndrome / mortality*
Anemia / epidemiology
Coronary Angiography
Coronary Artery Disease / mortality*
Erythrocyte Indices*
Hemoglobins / analysis
Middle Aged
Proportional Hazards Models
Prospective Studies
Reg. No./Substance:
Comment In:
Int J Cardiol. 2010 Nov 19;145(2):353; author reply 354-5   [PMID:  19995672 ]

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