| Relation between progression and regression of atherosclerotic left main coronary artery disease and serum cholesterol levels as assessed with serial long-term (> or =12 months) follow-up intravascular ultrasound. | |
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MedLine Citation:
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PMID: 14623804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The relation between serum lipids and risk of coronary events has been established, but there are no data demonstrating directly the relation between serum low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol versus serial changes in coronary plaque dimensions. METHODS AND RESULTS: We performed standard analyses of serial intravascular ultrasound (IVUS) studies of 60 left main coronary arteries obtained 18.3+/-9.4 months apart to evaluate progression and regression of mild atherosclerotic plaques in relation to serum cholesterol levels. Overall, there was (1) a positive linear relation between LDL cholesterol and the annual changes in plaque plus media (P&M) cross-sectional area (CSA) (r=0.41, P<0.0001) with (2) an LDL value of 75 mg/dL as the cutoff when regression analysis predicted on average no annual P&M CSA increase; (3) an inverse relation between HDL cholesterol and annual changes in P&M CSA (r=-0.30, P<0.02); (4) an inverse relation between LDL cholesterol and annual changes in lumen CSA (r=-0.32, P<0.01); and (5) no relation between LDL and HDL cholesterol and the annual changes in total arterial CSA (remodeling). Despite similar baseline IVUS characteristics, patients with an LDL cholesterol level > or =120 mg/dL showed more annual P&M CSA progression and lumen reduction than patients with lower LDL cholesterol. CONCLUSIONS: There is a positive linear relation between LDL cholesterol and annual changes in plaque size, with an LDL value of 75 mg/dL predicting, on average, no plaque progression. HDL cholesterol shows an inverse relation with annual changes in plaque size. |
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Authors:
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Clemens von Birgelen; Marc Hartmann; Gary S Mintz; Dietrich Baumgart; Axel Schmermund; Raimund Erbel |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2003-11-17 |
Journal Detail:
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Title: Circulation Volume: 108 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-12-05 Completed Date: 2004-01-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 2757-62 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Essen University, Essen, Germany. von.birgelen@freeler.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cholesterol
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blood* Cholesterol, HDL / blood Cholesterol, LDL / blood Coronary Artery Disease / drug therapy, ultrasonography* Coronary Vessels / ultrasonography* Demography Disease Progression Female Follow-Up Studies Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use Lipids / blood Male Middle Aged Predictive Value of Tests Remission Induction Time Ultrasonography, Interventional Vascular Patency |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Lipids; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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