| Relation between plasma renin activity, angiotensin, and aldosterone and blood pressure in mild untreated hypertension. | |
| | |
MedLine Citation:
|
PMID: 1269097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Plasma renin activity, arterial and venous angiotensin II (A II), plasma aldosterone, and sodium excretion were measured in a group of 101 patients with mild essential hypertension. For the total hour; arterial A II was 5.2 +/- 1.0 pg/ml; venous A II was 4.2 +/- 0.6 pg/ml; and plasma aldosterone was 5.0 +/- 0.45 ng/100 ml. All values were lower corresponding values for normal subjects on a high salt intake despite the fact that salt intake in the normal subjects exceeded that for the hypertensive group more than 3-fold. Moreover, when the range of diastolic blood pressure up to 114 mm Hg was divided into three successive class intervals of increasing severity, there was a negative correlation between diastolic blood pressure and both PRA and plasma aldosterone. Arterial A II showed an anomalous increase in the class interval 105-114 mm Hg, despite the fact that this group exhibited the lowest level of PRA. At diastolic blood pressures above 114 mm Hg, the PRA appears to rise again. The anomalous increase in arterial A II in the presence of marked suppression of PRA is consistent with the presence of a renin activator or accelerator factor in hypertensive plasma as postulated by others. It also identifies a possible mechanism whereby even small increases in PRA could exert an adverse effect on the hypertensive state. |
| | |
Authors:
|
W G Walker; J S Horvath; M A Moore; P Whelton; R P Russell |
Related Documents
:
|
16864147 - Effects of raloxifene therapy on plasma renin and aldosterone levels and blood pressure... 15273827 - Hemodynamic and hormonal actions of adrenomedullin. 17296647 - Plasma aldosterone is related to severity of obstructive sleep apnea in subjects with r... 2645767 - Clinical, biochemical, and hormonal changes after a single, large-volume paracentesis i... 12784777 - Left ventricular diastolic function in pregnancy-induced hypertension. 15249457 - Assessment of ventilation during the performance of elective endoscopic-guided percutan... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Circulation research Volume: 38 ISSN: 0009-7330 ISO Abbreviation: Circ. Res. Publication Date: 1976 Jun |
Date Detail:
|
Created Date: 1976-08-02 Completed Date: 1976-08-02 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0047103 Medline TA: Circ Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 470-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aldosterone / blood*, secretion Angiotensin II / blood* Arteries Blood Pressure* Diet Female Humans Hypertension / blood*, enzymology, physiopathology Male Middle Aged Natriuresis Renin / blood* Sodium Chloride Veins |
| Chemical | |
Reg. No./Substance:
|
11128-99-7/Angiotensin II; 52-39-1/Aldosterone; 7647-14-5/Sodium Chloride; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Combined effects of rate membrane potential, and drugs on maximum rate of rise (Vmax) of action pote...
Next Document: Plasma renin activity during exercise in the dog.