Document Detail

Relation between plasma adiponectin, high-sensitivity C-reactive protein, and coronary plaque components in patients with acute coronary syndrome.
MedLine Citation:
PMID:  18157956     Owner:  NLM     Status:  MEDLINE    
The present study investigated the relation between plasma high-sensitivity C-reactive protein (hs-CRP) and adiponectin and coronary plaque components in patients with acute coronary syndrome (ACS). Previous studies showed a pivotal role of inflammation in the progression of atherosclerosis and the prognostic value of several biomarkers. However, relations among inflammatory biomarkers and plaque characteristics were unknown. Ninety-three culprit plaques (ACS n = 50, non-ACS n = 43) and 56 nonculprit plaques (ACS n = 28, non-ACS n = 28) were analyzed using Virtual Histology intravascular ultrasound to examine relations among plasma hs-CRP, adiponectin, and ratios of each coronary plaque component. Plasma adiponectin was significantly lower and plasma hs-CRP was significantly higher in patients with than without ACS. Culprit plaques in patients with ACS had greater amounts of necrotic core plaque than those in patients without ACS. There was an inverse relation between serum hs-CRP and adiponectin with regard to necrotic core ratio in both culprit and nonculprit lesions in patients with ACS, but not those without ACS. In conclusion, increased plasma hs-CRP and hypoadiponectinemia might be related to the progression of ACS.
Hiromasa Otake; Junya Shite; Toshiro Shinke; Satoshi Watanabe; Yusuke Tanino; Daisuke Ogasawara; Takahiro Sawada; Ken-ichi Hirata; Mitsuhiro Yokoyama
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Publication Detail:
Type:  Journal Article     Date:  2007-11-26
Journal Detail:
Title:  The American journal of cardiology     Volume:  101     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-25     Completed Date:  2008-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  AIM; IM    
Department of Internal Medicine, Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
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MeSH Terms
Acute Coronary Syndrome / blood*
Adiponectin / blood*
Aged, 80 and over
Biological Markers / blood
C-Reactive Protein / analysis*
Case-Control Studies
Coronary Artery Disease / ultrasonography*
Coronary Vessels / ultrasonography
Middle Aged
Ultrasonography, Interventional
Ventricular Remodeling
Reg. No./Substance:
0/Adiponectin; 0/Biological Markers; 9007-41-4/C-Reactive Protein

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