Document Detail


Relation between optical configuration and immunogenicity of synthetic polypeptides.
MedLine Citation:
PMID:  5862399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Three random linear copolymers composed of two or three of the amino acids d-tyrosine, d-glutamic acid, d-alanine and d-lysine, and a branched multichain copolymer with a poly-d-lysine backbone and polymeric side chains of d-tyrosine and d-glutamic acid, were found to be non-antigenic in rabbits, by precipitin and passive cutaneous anaphylaxis, and in guinea pigs, by delayed hypersensitivity tests. The corresponding four copolymers of l-amino acids were shown to be antigenic by all the three criteria. 2. No immunological cross-reactions were observed between the polypeptides composed of d-amino acids and the corresponding l-amino acid copolymers. 3. Similarly, an azobenzenearsonic acid conjugate of poly-d-tyrosine was shown to be non-antigenic in guinea pigs, in contrast with an analogous conjugate of poly-l-tyrosine. Animals sensitized with the conjugate of poly-l-tyrosine did not exhibit delayed skin reactions, when cross-tested with the d-conjugate. 4. A linear polymer composed of d-tyrosine, l-glutamic acid and l-alanine was found to be immunogenic and to cross-react with the corresponding polymer composed exclusively of d-amino acids.
Authors:
F Borek; Y Stupp; S Fuchs; M Sela
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  96     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1965 Sep 
Date Detail:
Created Date:  1966-05-21     Completed Date:  1966-05-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  577-82     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alanine
Animals
Antigens / pharmacology*
Azo Compounds
Chemical Phenomena
Chemistry
Glutamates
Guinea Pigs
Hypersensitivity, Delayed / etiology
Lysine
Passive Cutaneous Anaphylaxis
Peptides / pharmacology*
Precipitin Tests
Rabbits
Tyrosine
Chemical
Reg. No./Substance:
0/Antigens; 0/Azo Compounds; 0/Glutamates; 0/Peptides; 55520-40-6/Tyrosine; 56-41-7/Alanine; 56-87-1/Lysine
Comments/Corrections

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