Document Detail

Relation between neonatal jaundice and oncostatin M, hepatocyte growth factor and soluble gp130 levels in umbilical cord.
MedLine Citation:
PMID:  18972232     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Oncostatin M (OSM), hepatocyte growth factor (HGF) and soluble glycoprotein 130 (sgp130) have been demonstrated to be involved in fetal liver development. In this study, we examined the relation between neonatal jaundice and OSM, gp130 or HGF levels in umbilical cord blood. DESIGN: A cross-sectional study of 160 neonates born at Okayama University Hospital. SETTING: Tertiary referral center serving a population of three million. METHODS: The serum concentrations of OSM, HGF and sgp130 in umbilical venous cord blood were measured and compared with the clinical records of these neonates. RESULTS: The HGF level was correlated to both gestational week (p=0.007) and birthweight (p=0.015), as well as to total bilirubin on Day 1 (p=0.032). In preterm neonates, the HGF levels were lower in neonates who received phototherapy (photo group) than in those who did not receive phototherapy (non-photo group) (p=0.002). In contrast, in term neonates, OSM levels were lower in the photo group than in the non-photo group (p=0.0003). CONCLUSIONS: These findings suggest that the phototherapy requirement for neonatal jaundice may be associated with lower umbilical HGF concentration in preterm neonates and with lower umbilical OSM concentration in term neonates.
Hideki Nakatsukasa; Hisashi Masuyama; Yoichiro Akahori; Seiji Inoue; Akio Masumoto; Yuji Hiramatsu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  87     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2008  
Date Detail:
Created Date:  2008-12-09     Completed Date:  2009-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1322-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
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MeSH Terms
Bilirubin / blood
Birth Weight / physiology
Cytokine Receptor gp130 / blood*
Fetal Blood / metabolism*
Gestational Age
Hepatocyte Growth Factor / blood*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / blood
Jaundice, Neonatal / blood*,  therapy
Oncostatin M / blood*
Reg. No./Substance:
106956-32-5/Oncostatin M; 133483-10-0/Cytokine Receptor gp130; 635-65-4/Bilirubin; 67256-21-7/Hepatocyte Growth Factor

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