Document Detail

Relation between left ventricular outflow tract obstruction and left ventricular shape in patients with hypertrophic cardiomyopathy: A cardiac magnetic resonance imaging study.
MedLine Citation:
PMID:  23906680     Owner:  NLM     Status:  Publisher    
BACKGROUND: Hypertrophic cardiomyopathies (HCM) are often associated with left ventricular (LV) outflow tract obstruction, which can explain symptoms and impact prognosis.
AIMS: To better understand the mechanisms that link obstruction and LV shape in HCM.
METHODS: Patients with HCM who underwent cardiac magnetic resonance (CMR) imaging were included retrospectively. Obstructive HCM was defined as LV outflow gradient more than 30mmHg at rest by transthoracic echocardiography. The LV shape and mitral angle were assessed by CMR. Results were compared with control subjects.
RESULTS: Mean LV-mitral angle was smaller in patients with obstructive HCM (n=29) than in patients with non-obstructive HCM (n=15) or control subjects (n=15) (80±5° vs 87±7° [P=0.0002] and 89±2° [P<0.0001]). Mean mitral papillary muscles angle was greater in patients with non-obstructive HCM than in patients with obstructive HCM or control subjects (136±17° vs 123±16° [P=0.007] and 118±10° [P=0.002]). Patients with non-obstructive HCM had a greater mean LV-aortic root angle than patients with obstructive HCM or control subjects (139±6° vs 135±7° [P=0.04] and 133±7° [P=0.03]).
CONCLUSION: There is a relation between morphological and functional parameters in HCM within which the mitral valve is probably part of pathophysiogenesis.
Romain Martin; Olivier Lairez; Nicolas Boudou; Simon Méjean; Thibault Lhermusier; Nicolas Dumonteil; Matthieu Berry; Thomas Cognet; Pierre Massabuau; Meyer Elbaz; Hervé Rousseau; Michel Galinier; Didier Carrié
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-29
Journal Detail:
Title:  Archives of cardiovascular diseases     Volume:  -     ISSN:  1875-2128     ISO Abbreviation:  Arch Cardiovasc Dis     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-8-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101465655     Medline TA:  Arch Cardiovasc Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Masson SAS. All rights reserved.
Department of Cardiology, Rangueil University Hospital, 1, avenue Jean-Poulhès, TSA 50032, 31059 Toulouse cedex 9, France; Cardiac Imaging Center, University Hospital of Toulouse, Toulouse, France.
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