Document Detail


Relation between interleukin-6 level and subclinical intracranial large-artery atherosclerosis.
MedLine Citation:
PMID:  17604035     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The levels of systemic inflammatory markers have been shown to predict future cardiovascular events, but whether they are associated with intracranial large-artery atherosclerosis is uncertain. We investigated the relation between the level of inflammatory markers interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP) and subclinical intracranial large-artery atherosclerosis in patients with risk factors for atherosclerosis. METHODS: Magnetic resonance angiography (MRA) was performed in 226 Japanese patients age range, 45-87 years without a history of cerebrovascular disease. Serum IL-6 and hsCRP and conventional risk factors for atherosclerosis were assessed. RESULTS: Forty-six patients (20.4%) were found by MRA to have one or more intracranial steno-occlusive lesions. Mean IL-6 levels were higher in patients with intracranial large-artery atherosclerosis than in those without. In addition, patients in the highest IL-6 tertile had higher unadjusted odds ratio (OR) for intracranial large-artery atherosclerosis than that of those in the lowest tertile (OR 3.25, 95% CI; 1.42-7.39). These associations were only slightly attenuated upon adjustment for conventional atherosclerotic risk factors and carotid intima-media thickness. CONCLUSIONS: Increased levels of IL-6 appear to be associated with intracranial large-artery disease, suggesting a role for the inflammatory process in atherosclerosis of intracranial large arteries.
Authors:
Taku Hoshi; Kazuo Kitagawa; Hiroshi Yamagami; Shigetaka Furukado; Hidetaka Hougaku; Masatsugu Hori
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Publication Detail:
Type:  Journal Article     Date:  2007-06-29
Journal Detail:
Title:  Atherosclerosis     Volume:  197     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-25     Completed Date:  2008-03-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  326-32     Citation Subset:  IM    
Affiliation:
Osaka University, Graduate School of Medicine, Division of Stroke Research, Department of Cardiovascular Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan. thoshi@medone.med.osaka-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Atherosclerosis / blood*,  epidemiology,  immunology*,  pathology
Biological Markers / blood*
C-Reactive Protein / metabolism
Diabetes Complications / epidemiology
Female
Humans
Hypertension / epidemiology
Interleukin-6 / blood*
Magnetic Resonance Angiography
Male
Middle Aged
Myocardial Ischemia / epidemiology
Predictive Value of Tests
Prevalence
Risk Factors
Severity of Illness Index
Smoking / epidemiology
Vasculitis / blood,  epidemiology,  immunology,  pathology
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-6; 9007-41-4/C-Reactive Protein

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