| Relation between exercise capacity and left ventricular systolic versus diastolic function during exercise in patients after myocardial infarction. | |
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MedLine Citation:
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PMID: 11352078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It is known that left ventricular systolic function at rest does not correlate well with exercise capacity of patients with heart failure. However, the contribution of left ventricular diastolic dysfunction, especially during exercise, to exercise capacity of cardiac patients remains to be determined. OBJECTIVE: To determine the impact of left ventricular systolic and diastolic function during exercise on exercise capacity of patients with left ventricular dysfunction after myocardial infarction. METHODS: A symptom-limited exercise test was performed with measurements for hemodynamics and uptake of oxygen (Vo2) of 26 men who had previously suffered myocardial infarction. These patients were divided into two groups according to their peak Vo2 (group 1 with peak Vo2 > or = 16 ml/kg per min, n= 13; and group 2 with peak Vo2 < 16 ml/kg per min, n= 13). Pulmonary arterial pressure, left ventricular and systemic arterial pressure, and cardiac output were measured at rest and during exercise. RESULTS: At rest, there was no difference between the two groups in terms of hemodynamic parameters except for minimal dP/dt, minimal left ventricular pressure (LVP) and time constant for decay of left ventricular pressure (tau). During peak exercise, cardiac output, left ventricular end-diastolic pressure (EDP), minimal dP/dt, minimal LVP, and tau for the two groups were significantly different. Furthermore, peak Vo2 was significantly correlated with T, minimal LVP, minimal dP/dt, EDP, and maximal dP/dt during peak exercise for the whole group of patients. CONCLUSION: Left ventricular diastolic function during exercise, i.e. diastolic reserve, may be an important determinant of exercise capacity of patients with left ventricular dysfunction after myocardial infarction. |
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Authors:
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T Miyashita; Y Okano; H Takaki; T Satoh; Y Kobayashi; Y Goto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Coronary artery disease Volume: 12 ISSN: 0954-6928 ISO Abbreviation: Coron. Artery Dis. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-05-15 Completed Date: 2001-09-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9011445 Medline TA: Coron Artery Dis Country: England |
Other Details:
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Languages: eng Pagination: 217-25 Citation Subset: IM |
Affiliation:
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Department of Medicine, National Cardiovascular Center, Suita, Osaka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Diastole / physiology* Exercise / physiology* Exercise Test Exercise Tolerance / physiology* Hemodynamics / physiology Humans Male Middle Aged Myocardial Infarction / complications*, physiopathology* Pulmonary Ventilation / physiology Systole / physiology* Ventricular Dysfunction, Left / etiology*, physiopathology* |
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