Document Detail

Relation between exercise capacity and left ventricular systolic versus diastolic function during exercise in patients after myocardial infarction.
MedLine Citation:
PMID:  11352078     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It is known that left ventricular systolic function at rest does not correlate well with exercise capacity of patients with heart failure. However, the contribution of left ventricular diastolic dysfunction, especially during exercise, to exercise capacity of cardiac patients remains to be determined. OBJECTIVE: To determine the impact of left ventricular systolic and diastolic function during exercise on exercise capacity of patients with left ventricular dysfunction after myocardial infarction. METHODS: A symptom-limited exercise test was performed with measurements for hemodynamics and uptake of oxygen (Vo2) of 26 men who had previously suffered myocardial infarction. These patients were divided into two groups according to their peak Vo2 (group 1 with peak Vo2 > or = 16 ml/kg per min, n= 13; and group 2 with peak Vo2 < 16 ml/kg per min, n= 13). Pulmonary arterial pressure, left ventricular and systemic arterial pressure, and cardiac output were measured at rest and during exercise. RESULTS: At rest, there was no difference between the two groups in terms of hemodynamic parameters except for minimal dP/dt, minimal left ventricular pressure (LVP) and time constant for decay of left ventricular pressure (tau). During peak exercise, cardiac output, left ventricular end-diastolic pressure (EDP), minimal dP/dt, minimal LVP, and tau for the two groups were significantly different. Furthermore, peak Vo2 was significantly correlated with T, minimal LVP, minimal dP/dt, EDP, and maximal dP/dt during peak exercise for the whole group of patients. CONCLUSION: Left ventricular diastolic function during exercise, i.e. diastolic reserve, may be an important determinant of exercise capacity of patients with left ventricular dysfunction after myocardial infarction.
T Miyashita; Y Okano; H Takaki; T Satoh; Y Kobayashi; Y Goto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Coronary artery disease     Volume:  12     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-15     Completed Date:  2001-09-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  217-25     Citation Subset:  IM    
Department of Medicine, National Cardiovascular Center, Suita, Osaka, Japan.
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MeSH Terms
Diastole / physiology*
Exercise / physiology*
Exercise Test
Exercise Tolerance / physiology*
Hemodynamics / physiology
Middle Aged
Myocardial Infarction / complications*,  physiopathology*
Pulmonary Ventilation / physiology
Systole / physiology*
Ventricular Dysfunction, Left / etiology*,  physiopathology*

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