Document Detail

Relation between essential fatty acid metabolism and gastrointestinal symptoms in cystic fibrosis.
MedLine Citation:
PMID:  2701926     Owner:  NLM     Status:  MEDLINE    
Studies in our laboratory have supported the hypothesis, that the basic defect in cystic fibrosis increases the metabolism of essential fatty acids and thereby gradually gives rise to essential fatty acid deficiency, which is a well documented finding in most cases with this disease. Both the increased metabolism--giving high liberation of arachidonic acid and its metabolic products, i.e. different eicosanoids--and the subsequent essential fatty acid deficiency will cause gastrointestinal symptoms and the sequence of this development will mirror the natural history of the disease. Clinical data and results from animal research are discussed in relation to gastrointestinal symptoms and signs of cystic fibrosis.
B Strandvik
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta paediatrica Scandinavica. Supplement     Volume:  363     ISSN:  0300-8843     ISO Abbreviation:  Acta Paediatr Scand Suppl     Publication Date:  1989  
Date Detail:
Created Date:  1990-10-26     Completed Date:  1990-10-26     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  0173166     Medline TA:  Acta Paediatr Scand Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  58-63; discussion 63-5     Citation Subset:  IM    
Department of Paediatrics, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
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MeSH Terms
Cystic Fibrosis / metabolism,  physiopathology*
Digestive System / metabolism,  physiopathology*
Eicosanoids / biosynthesis
Fatty Acids, Essential / deficiency,  metabolism*
Linoleic Acids / deficiency
Reg. No./Substance:
0/Eicosanoids; 0/Fatty Acids, Essential; 0/Linoleic Acids

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