| Relation between dehydroepiandrosterone sulfate and blood pressure levels in a population-based sample. | |
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MedLine Citation:
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PMID: 10604493 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endogenous dehydroepiandrosterone sulfate (DHEAS) levels have been reported to be positively related to blood pressure levels. To further analyze this association, we quantified DHEAS in middle-aged subjects (mean age +/-SEM: 57.8+/-0.1 years) of a population-based sample (n = 646). DHEAS levels were higher in hypertensive as compared with normotensive individuals (1.26+/-0.04 v. 1.09+/-0.03 microg/mL, P = .01). After adjustment for age, gender, and body mass index, DHEAS levels were significantly related to systolic blood pressure (P = .01). In addition, in a subgroup of individuals without antihypertensive medication adjusted DHEAS levels were significantly related to systolic and diastolic blood pressure (n = 461; P<.05, both). DHEAS levels were also related to aldosterone (r = 0.15; P = .002) and androstenedione (its main metabolite; r = 0.66; P<.001) but not to renin levels. Like DHEAS, aldosterone, but not androstenedione, was significantly related to blood pressure levels and hypertension status. In a regression analysis that accounted for aldosterone and renin levels, both DHEAS and aldosterone kept their significant relationships with systolic blood pressure levels. Taken together, we observed a consistent positive association between endogenous DHEAS and systolic blood pressure levels that was independent of other, similarly regulated, adrenal steroids. |
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Authors:
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H Schunkert; H W Hense; T Andus; G A Riegger; R H Straub |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of hypertension Volume: 12 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 1999 Nov |
Date Detail:
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Created Date: 2000-01-06 Completed Date: 2000-01-06 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1140-3 Citation Subset: IM |
Affiliation:
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Klinik und Poliklinik für Innere Medizin I & II, University of Regensburg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aldosterone / blood Androstenedione / blood Biological Markers / blood Blood Pressure* Dehydroepiandrosterone Sulfate / blood* Female Humans Hypertension / blood* Male Middle Aged Prognosis Renin / blood Retrospective Studies Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 52-39-1/Aldosterone; 63-05-8/Androstenedione; 651-48-9/Dehydroepiandrosterone Sulfate; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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