| Relation between blue-on-yellow perimetry and optical coherence tomography in normal tension glaucoma. | |
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MedLine Citation:
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PMID: 20648075 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the relation between blue-on-yellow perimetry (B/YP) indices and optical coherence tomography (OCT) parameters in normal tension glaucoma (NTG) patients and to investigate the diagnostic ability of B/YP and OCT in discriminating NTG from normal eyes. DESIGN: Cross-sectional study. PARTICIPANTS: Eighty normal subjects (80 eyes) and 80 NTG patients (80 eyes) were enrolled in the study. METHODS: All patients underwent white-on-white perimetry, B/YP, and OCT measurement. The correlation between B/YP indices and OCT parameters was analyzed. The area of the receiver operating characteristic (ROC) curve was calculated to discriminate NTG patients from normal subjects. RESULTS: A highly significant correlation was found between B/YP mean deviation (MD) and average thickness of the retinal nerve fibre layer (r2 = 0.707, p = 0.000), and a moderately significant correlation was found between B/YP MD and temporal average (r2 = 0.437, p = 0.010) in the early NTG patients. A mildly or moderately significant correlation was found between B/YP MD and average thickness, inferior average, temporal average, superior maximum, and maximum-minimum (r2 = 0.212-0.498, p = 0.001-0.048) in the moderate or late NTG patients. The area under the ROC curve at the B/YP MD was 0.896, and the 3 OCT parameters with the widest area under the curve were average thickness (0.957), inferior average (0.932), and superior average (0.913). Average thickness showed the highest sensitivity (93%) with specificities at 90% and 80%. CONCLUSIONS: The significant correlation between B/YP indices and OCT parameters in NTG patients suggests that the 2 tests detect similar areas or amounts of NTG damage and could be used for NTG early diagnosis. |
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Authors:
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Yisheng Zhong; Xiaoqing Zhou; Yu Cheng; Lieqin Xie |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie Volume: 45 ISSN: 0008-4182 ISO Abbreviation: Can. J. Ophthalmol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045312 Medline TA: Can J Ophthalmol Country: Canada |
Other Details:
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Languages: eng Pagination: 494-500 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Ruijin Hospital Affiliated Shanghai Jiaotong University, Shanghai, China. yszhong68@yahoo.com.cn |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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