Document Detail

Relation between asymmetric dimethylarginine (ADMA) and hearing loss in patients with renal impairment.
MedLine Citation:
PMID:  18925527     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hearing loss is common in patients with CRF. The exact etiology of this complication is not known, and little can be done to ameliorate the disorder. ADMA is found to be high in CRF patients. We studied the relation between ADMA and hearing loss in patients with CRF under conservative treatment. METHODS: The study was carried out on 40 patients with renal impairment under conservative treatment (group 1) and 30 normal control subjects (group 2). For both groups' medical history and examination, biochemical tests, otological examination, pure tone audiometry, high sensitivity CRP, and asymmetric dimethylarginine (ADMA) were completed. RESULTS: High-frequency hearing impairment was the predominant auditory dysfunction in CRF patients who showed worse high-tone hearing level on pure tone audiometry as compared with the controls (p < .001). Multiple regression analysis for hearing level at high frequency in group 1 shows that significant determinants of hearing level are ADMA (p = 0.002), high sensitivity CRP (p = 0.02), duration of renal disease (p = 0.01), diabetes mellitus (p < 0.001), and serum creatinine (p = 0.008). No correlation was found between hearing loss with age, gender, smoking, hematocrit, or lipid parameters. CONCLUSION: Patients with CRF under conservative treatment often experience a significant frequency hearing loss. Such a hearing disorder is mainly affected by duration and degree of renal disease, presence of DM, and level of hsCRP and ADMA. There is a close correlation between ADMA and hearing loss. Thus, ADMA could be an important factor causing hearing loss in those patients. Modifying this factor can be of value to ameliorate this common complication.
Saeed Abdelwhab; Gamal Lotfy; Sahar Abdelmaksoud
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  30     ISSN:  1525-6049     ISO Abbreviation:  Ren Fail     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-17     Completed Date:  2009-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  877-83     Citation Subset:  IM    
Department of Internal Medicine and Nephrology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
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MeSH Terms
Arginine / analogs & derivatives*,  blood
C-Reactive Protein / metabolism
Case-Control Studies
Creatinine / blood
Hearing Loss, Sensorineural / blood*,  diagnosis,  etiology*
Lipids / blood
Middle Aged
Renal Insufficiency, Chronic / blood*,  complications*,  therapy
Risk Factors
Reg. No./Substance:
0/Lipids; 30315-93-6/N,N-dimethylarginine; 60-27-5/Creatinine; 74-79-3/Arginine; 9007-41-4/C-Reactive Protein

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