Document Detail

Relation between ascending aortic pressures and outcomes in patients with angiographically demonstrated coronary artery disease.
MedLine Citation:
PMID:  16125487     Owner:  NLM     Status:  MEDLINE    
We prospectively followed 324 men, who underwent coronary angiography, for 1,161 +/- 418 days. We analyzed the association between ascending aortic pressures measured during cardiac catheterization and the risk of all-cause mortality and a combined end point of major adverse cardiovascular events (MACEs), including unstable angina pectoris, myocardial infarction, coronary revascularization, stroke, or death. Pulse pressure significantly predicted MACEs (hazard ratio [HR] per 10 mm Hg increase 1.09, 95% confidence interval [CI] 1.002 to 1.17, p = 0.04). Diastolic blood pressure (BP) inversely correlated with the risk of MACEs (HR per 10 mm Hg increase 0.85, 95% CI 0.74 to 0.98, p = 0.02). These correlations remained significant after adjusting for other predictors and potential confounders. The association between lower diastolic BP with the risk of MACEs was more pronounced in patients with triple-vessel coronary artery disease (p for interaction = 0.03). Peripheral diastolic BP (but not pulse pressure) correlated inversely with the risk of MACEs (HR 0.87 per 10 mm Hg increase, 95% CI 0.75 to 0.998, p = 0.047). Aortic pulse pressure significantly predicted death (HR per 10 mm Hg increase 1.18, 95% CI 1.05 to 1.33, p = 0.004), and aortic diastolic BP correlated inversely with the risk of death (HR 0.76, 95% CI 0.62 to 0.94, p = 0.01).
Julio A Chirinos; Juan P Zambrano; Simon Chakko; Anila Veerani; Alan Schob; Guido Perez; Armando J Mendez
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  96     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-29     Completed Date:  2005-10-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  645-8     Citation Subset:  AIM; IM    
University of Miami School of Medicine, Miami, Florida, USA.
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MeSH Terms
Aorta / physiopathology*
Blood Pressure / physiology*
Coronary Angiography
Coronary Disease / physiopathology,  radiography*
Follow-Up Studies
Heart Catheterization
Middle Aged
Outcome Assessment (Health Care)
Predictive Value of Tests
Prospective Studies
Risk Factors
Comment In:
Am J Cardiol. 2006 Feb 15;97(4):590-1   [PMID:  16461063 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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