| Relation between RLP-triglyceride to RLP-cholesterol ratio and particle size distribution in RLP-cholesterol profiles by HPLC. | |
| | |
MedLine Citation:
|
PMID: 10807977 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Remnant-Like Particles (RLP) isolated by an immunoseparation method are heterogeneous in their physical and biochemical properties. The objective of this study was to examine the relation between RLP-triglyceride (RLP-TG) to RLP-cholesterol (RLP-C) ratio and particle size distribution in RLP-C profiles from patients with hyperlipoproteinemia by HPLC. RLP were isolated from serum samples from 147 subjects. RLP-C and RLP-TG were quantified by respective enzymatic methods. Particle sizes of the RLP were measured using HPLC with 4 connected TSKgel LipopropakXL columns. Based on HPLC profiles of RLP-C from individual subjects, three different types were classified: predominantly LDL, predominantly VLDL, and mostly VLDL types. All patients with type III hyperlipidemia were mostly VLDL type but with smaller particle size of VLDL (32 nm) than other subjects. Severe hypertriglyceridemic (TG>4.52 mmoll(-1)) subjects were mostly VLDL type with large particle size (41 nm). As for all subjects (n=105) without predominantly LDL type, a significant correlation between RLP particle size and RLP-TG to RLP-C ratio (r=0. 432, P<0.001) was obtained, but not in case of serum TG to RLP-C ratio (r=0.062). It suggests that RLP-TG to RLP-C ratio might be used for discrimination of atherogenic smaller-sized lipoprotein from larger-sized TG-rich lipoprotein remnants. |
| | |
Authors:
|
M Okazaki; S Usui; N Tada; T Nakano; K Nakajima |
Related Documents
:
|
4071847 - Preemployment medical examinations in a compressed air tunneling project in hong kong. 6873637 - The dementia patient: evaluation and care. 8864707 - Magnetic resonance volumetry of the cerebellum in epileptic patients after phenytoin ov... 20182117 - Perspective: anticipating the challenges of reforming the united states medical licensi... 11998537 - Inappropriate prescriptions for the aging population of the united states: an analysis ... 10275857 - When "patients" become "consumers.". |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinica chimica acta; international journal of clinical chemistry Volume: 296 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2000 Jun |
Date Detail:
|
Created Date: 2000-07-14 Completed Date: 2000-07-14 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 135-49 Citation Subset: IM |
Affiliation:
|
Laboratory of Chemistry, College of Liberal Arts and Sciences, Tokyo Medical and Dental University, 2-8-30, Kohnodai, Ichikawa-shi, Chiba, Japan. okazaki.cul@cul.tmd.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Apolipoproteins
/
blood* Cholesterol* Chromatography, High Pressure Liquid Humans Hyperlipoproteinemia Type II / blood Hyperlipoproteinemia Type III / blood Hyperlipoproteinemia Type IV / blood Hyperlipoproteinemias / blood Hypertriglyceridemia / blood Lipoproteins / blood* Lipoproteins, LDL / blood Lipoproteins, VLDL / blood Particle Size Triglycerides / blood* |
| Chemical | |
Reg. No./Substance:
|
0/Apolipoproteins; 0/Lipoproteins; 0/Lipoproteins, LDL; 0/Lipoproteins, VLDL; 0/Triglycerides; 0/remnant-like particle cholesterol; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oxidized lipoprotein(a) increases the expression of platelet-derived growth factor-B in human umbili...
Next Document: Spectrophotometric assay for serum platelet-activating factor acetylhydrolase activity.