Document Detail

Relation of baseline serum potassium levels to angiographic findings in patients with known or suspected coronary artery disease.
MedLine Citation:
PMID:  19373212     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In experimental animal studies, potassium has been demonstrated to protect against the development of atherosclerosis through a variety of mechanisms. Data regarding the role of potassium in the development of human atherosclerosis are sparse. The objective of this study was to determine the association between plasma potassium levels and angiographically defined coronary artery disease (CAD).
METHODS: In a cohort of 389 male patients undergoing coronary angiography for a variety of clinical indications, the association between baseline serum potassium levels and the extent of angiographically defined atherosclerosis was analyzed. Adjustments were made for clinical and laboratory variables (including inflammatory markers) known to be associated with atherosclerosis.
RESULTS: By multivariate logistic regression analysis, baseline serum potassium levels were an independent predictor of the presence of multivessel disease (odds ratio (OR) 1.31, 95% confidence interval (CI) 1.01-1.69; P < 0.05). In addition, in the non-myocardial infarction subpopulation of patients, serum potassium was also an independent predictor of the presence of multivessel disease by multivariate logistic regression analysis (OR 1.34, 95% CI, 1.02-1.76; P < 0.05). In the myocardial infarction (MI) subpopulation, serum potassium was not a predictor of multivessel disease, possibly due to the confounding effect of hypokalemia known to be present during MI.
CONCLUSIONS: These data demonstrate that a simple baseline serum potassium level is independently associated with the presence of multivessel disease, even in the context of clinical CAD risk factors and other established inflammatory markers.
Erdal Cavusoglu; Vineet Chopra; Amit Gupta; Palak U Choksi; Cyril Ruwende; Sunitha Yanamadala; William H Frishman; David J Pinsky; Jonathan D Marmur
Publication Detail:
Type:  Journal Article     Date:  2009-04-16
Journal Detail:
Title:  American journal of hypertension     Volume:  22     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-22     Completed Date:  2009-08-27     Revised Date:  2011-06-30    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  754-62     Citation Subset:  IM    
Division of Cardiology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, New York, USA.
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MeSH Terms
Atherosclerosis / blood,  radiography
Cohort Studies
Coronary Angiography*
Coronary Artery Disease / blood*,  radiography
Logistic Models
Middle Aged
Myocardial Infarction / blood
Potassium / blood*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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