| Relation of Vascular Growth Factors with CT-Derived Measures of Body Fat Distribution: The Framingham Heart Study. | |
| | |
MedLine Citation:
|
PMID: 22170711 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background:Visceral adiposity is associated with metabolic risk. Given that angiogenesis is a key feature of adipogenesis, variation in the association of levels of circulating vascular growth factors (and their soluble receptors) with distinct body fat compartments may explain differences in the systemic pathogenicity of regional fat depots.Methods and Results:Four body fat compartments [visceral adipose tissue (VAT), sc adipose tissue (SAT), thoracic periaortic fat, and pericardial fat] derived from computed tomography were related to serum concentrations of vascular endothelial growth factor (VEGF), the soluble VEGF receptor (fms-like tyrosine kinase-1), hepatocyte growth factor (HGF), and angiopoietin-2 and its soluble receptor (soluble tyrosine kinase with immunoglobulin-like and EGF-like domains 2 sTie-2) in 1806 Framingham Heart Study participants (mean age 44.9 yr, 44.5% women). In multivariable models, we observed positive associations between several fat compartments and VEGF and HGF levels. The magnitude of the associations were similar for VAT, SAT, and periaortic fat. We observed effect modification by sex. A stronger association was observed between VAT and HGF levels in women; higher VAT and periaortic fat were jointly associated with higher HGF concentrations (P = 0.02 and P = 0.051, respectively). In women within the highest tertile of VAT, HGF levels significantly increased with higher periaortic fat (P = 0.0005).Conclusions:In our large community-based sample, greater adiposity was associated with higher circulating growth factor levels in general. Additional studies are warranted to confirm the stronger association of VAT and periaortic fat with HGF in women and to examine its potential contribution to the sex-related differences in cardiometabolic risk. |
| | |
Authors:
|
Bernhard M Kaess; Alison Pedley; Joseph M Massaro; Martin G Larson; Erin Corsini; Udo Hoffmann; Holly M Smith; Douglas B Sawyer; Ramachandran S Vasan; Caroline S Fox |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-14 |
Journal Detail:
|
Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
National Heart, Lung, and Blood Institute's Framingham Heart Study (B.M.K., A.P., M.G.L., R.S.V., C.S.F.), Framingham, Massachusetts 01702; Department for Internal Medicine II (B.M.K.), University of Regensburg, D-93053 Regensburg, Germany; Department of Biostatistics (J.M.M., M.G.L.), Boston University School of Public Health, Boston, Massachusetts 02118; Department of Mathematics and Statistics (M.G.L.) and Sections of Preventive Medicine and Epidemiology and Cardiology (R.S.V.), Department of Medicine, Boston University, Boston University, Boston, Massachusetts 02215; Radiology Department (E.C., U.H.), Massachusetts General Hospital, Boston, Massachusetts 02114; Brigham and Women's Division of Endocrinology, Hypertension, and Metabolism (C.S.F.), Harvard Medical School (U.H., C.S.F.), Boston, Massachusetts 02115; and Cardiovascular Division (H.M.S., D.B.S.), Vanderbilt University, Nashville, Tennessee 37232. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A Missense Mutation in the Human Cytochrome b5 Gene causes 46,XY Disorder of Sex Development due to ...
Next Document: Toward a Better Understanding of Functional Ovarian Reserve: AMH (AMHo) and FSH (FSHo) Hormone Ratio...