Document Detail


Relation of thoracic aortic distensibility to left ventricular area (from the Multi-Ethnic Study of Atherosclerosis [MESA]).
MedLine Citation:
PMID:  24210674     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Decreased arterial compliance is an early manifestation of adverse structural and functional changes within the vessel wall. Its correlation with left ventricular (LV) area on computed tomography, a marker of LV remodeling, has not been well demonstrated. The aim of this study was to test the hypothesis that decreasing aortic compliance and increasing arterial stiffness are independently associated with increased LV area. The study population consisted of 3,540 patients (mean age 61 ± 10 years, 46% men) from the Multi-Ethnic Study of Atherosclerosis (MESA) who underwent aortic distensibility (AD) assessment on magnetic resonance imaging and LV area measurement on computed tomography (adjusted to body surface area). Multivariate logistic regression was performed to assess the association between body surface area-normalized LV area >75th percentile and AD after adjusting for baseline clinical, historical, and imaging covariates. Mean LV area index was 2,153 cm(2), and mean AD was 1.84 × 10(3) mm Hg(-1). Subjects in the lowest AD quartile were older, with higher prevalence rates of hypertension, diabetes, and hypercholesterolemia (p <0.05 for all comparisons). Using multivariate linear regression adjusting for demographics, traditional risk factors, coronary artery calcium, and C-reactive protein, each SD decrease was associated with an 18-cm(2) increase in LV area. In addition, decreasing AD quartiles were independently associated with increasing LV area index, defined as >75th percentile. In conclusion, in this multiethnic cohort, reduced AD was associated with increased LV area. Longitudinal studies are needed to determine if decreased distensibility precedes and directly influences increased LV area.
Authors:
Mouaz H Al-Mallah; Khurram Nasir; Ronit Katz; Joao A Lima; David A Bluemke; Roger S Blumenthal; Songshou Mao; W Gregory Hundley; Matthew J Budoff
Related Documents :
23978364 - Implementation of contemporary oral antiplatelet treatment guidelines in patients with ...
22961594 - Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes...
23900044 - Long-term implications of further st elevation during thrombolytic therapy on left vent...
24509284 - Rapid endovascular catheter core cooling combined with cold saline as an adjunct to per...
17878634 - Comparison of the incidence of acute coronary event after balloon angioplasty vs. stent...
18627484 - Anterior spinal cord infarction caused by fibrocartilaginous embolism.
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural     Date:  2013-10-08
Journal Detail:
Title:  The American journal of cardiology     Volume:  113     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2013-12-16     Completed Date:  2014-02-13     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  178-82     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Aorta, Thoracic / physiopathology*
Atherosclerosis / diagnosis,  ethnology,  physiopathology*
Elasticity
Electrocardiography
Ethnic Groups*
Female
Heart Ventricles / physiopathology*
Humans
Incidence
Magnetic Resonance Imaging
Male
Middle Aged
Prevalence
Retrospective Studies
Tomography, X-Ray Computed
United States / epidemiology
Vasodilation / physiology*
Grant Support
ID/Acronym/Agency:
N01-HC-95159/HC/NHLBI NIH HHS; N01-HC-95165/HC/NHLBI NIH HHS; N01-HC-95169/HC/NHLBI NIH HHS; R01 HL071739/HL/NHLBI NIH HHS; R01 HL071739/HL/NHLBI NIH HHS; UL1 TR001079/TR/NCATS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The effect of a diabetes education programme (PRIMAS) for people with type 1 diabetes: Results of a ...
Next Document:  Comparison of Outcomes in Patients ?85 Versus >85 Years of Age Undergoing Transcatheter Aortic-Valve...