| Relation of Systemic Autoantibodies to the Number of Extraglandular Manifestations in Primary Sjögren's Syndrome: A Retrospective Analysis of 65 Patients in the Netherlands. | |
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MedLine Citation:
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PMID: 20864144 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVES: Extraglandular manifestations (EGM) are often seen in patients with primary Sjögren's syndrome and are probably due to a (more) disturbed immune system. Their relation to systemic autoantibodies remains controversial. We hypothesized that positive serology as reflected by the presence of 1 of more systemic autoantibodies is related to the number of EGM. METHODS: To this purpose, all patients, visiting a large nonacademic teaching hospital, with primary Sjögren's syndrome, according to the revised American-European classification criteria of 2002, were retrospectively analyzed. RESULTS: In this group of 65 patients, systemic autoantibodies were abundant: anti-Sjögren syndrome A antigen (SSA) and/or anti-Sjögren syndrome B antigen (SSB) (80%), immunoglobulinM-Rheumatoid factor (IgM-RF) (68%), and anti-nuclear antibodies (ANA) (77%). Their presence was often found together and correlated to the presence of hypergammaglobulinemia. There was a statistically significant correlation between the number of systemic autoantibodies and the total number of EGM (P = 0.025). Anti-SSA was the strongest predictor of the presence of EGM (OR = 4.67, P = 0.024). CONCLUSIONS: These findings indicate that a more disturbed immune system, as reflected by B-cell hyperactivity, with autoantibody formation and hypergammaglobulinemia, is associated with more systemic manifestations in patients with primary Sjögren's syndrome. |
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Authors:
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Evert-Jan Ter Borg; Anna P Risselada; Johannes C Kelder |
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Publication Detail:
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Type: Journal Article Date: 2010-09-22 |
Journal Detail:
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Title: Seminars in arthritis and rheumatism Volume: 40 ISSN: 1532-866X ISO Abbreviation: Semin. Arthritis Rheum. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1306053 Medline TA: Semin Arthritis Rheum Country: United States |
Other Details:
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Languages: eng Pagination: 547-51 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Rheumatology, St. Antonius Hospital, Nieuwegein, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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