Document Detail

Relation of pulse pressure to blood pressure response to exercise in patients with hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  21184995     Owner:  NLM     Status:  MEDLINE    
Almost one third of patients with hypertrophic cardiomyopathy (HC) will have an abnormal blood pressure response (ABPR) to exercise, and this has been associated with a greater risk of sudden cardiac death. In the present study, we examined the association between the steady (mean arterial pressure) and pulsatile (pulse pressure) blood pressure components as they relate to ABPR in patients with HC (n = 70). All patients completed a standard Bruce protocol during symptom-limited stress testing with concurrent hemodynamic measurements. Pulse pressure (PP) was significantly greater in patients with HC with an ABPR (n = 19) than in the patients with HC without an ABPR to exercise (p <0.05). According to binary logistic regression analysis, PP at rest was a significant predictor of ABPR in patients with HC (p <0.05). Mean arterial pressure was not significantly different between the 2 groups, nor was it a predictor of an ABPR in the presence of HC. Those within the greatest tertile of PP at rest were 4.8 times more likely to have an ABPR than those within the lowest PP tertile (95% confidence interval 1.24 to 18.2, p <0.05). In conclusion, elevations in PP at rest might identify patients with HC at a greater risk of having an ABPR during exercise.
Kevin S Heffernan; Martin S Maron; Eshan A Patvardhan; Richard H Karas; Jeffrey T Kuvin;
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-12-22
Journal Detail:
Title:  The American journal of cardiology     Volume:  107     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-07     Completed Date:  2011-04-08     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  600-3     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Blood Pressure*
Cardiomyopathy, Hypertrophic / complications*,  physiopathology*
Death, Sudden, Cardiac / etiology*
Exercise Test* / adverse effects
Middle Aged
Statistics, Nonparametric
Grant Support
Comment In:
Am J Cardiol. 2011 Aug 15;108(4):614   [PMID:  21807136 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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