Document Detail

Relation of P-S4 interval to left ventricular end-diastolic pressure.
MedLine Citation:
PMID:  7059403     Owner:  NLM     Status:  MEDLINE    
Reports have suggested that the interval between P wave onset and the fourth heart sound (P-S4 interval) reflects changes in left ventricular myocardial stiffness. We made simultaneous measurements of the P-S4 or atrial electrogram to S4 (A-S4) interval and left ventricular pressure in 19 patients with coronary artery disease who were studied before and after atrial pacing. Thirteen patients developed angina accompanied by significant rises in their end-diastolic pressure and a consistent decrease in P-S4 or A-S4 interval; whereas the six patients who had atrial pacing without the development of angina had no change in end-diastolic pressure, P-S4, or A-S4 interval. The resting data showed in inverse correlation between left ventricular end-diastolic pressure and the P-S4 interval. In addition, the P-S4 interval let us discriminate between patients with normal and abnormal end-diastolic pressure (greater than 15 mmHg).
J N Schapira; R E Fowles; R E Bowden; E L Alderman; R L Popp
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  47     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-05-27     Completed Date:  1982-05-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  270-6     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Cardiac Pacing, Artificial
Coronary Disease / physiopathology*
Heart / physiopathology*
Heart Atria / physiopathology
Heart Sounds
Heart Ventricles / physiopathology
Middle Aged

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