| Relation of Framingham risk score to subclinical atherosclerosis evaluated across three arterial sites. | |
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MedLine Citation:
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PMID: 18805105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Framingham risk score (FRS) is widely used in clinical practice to identify subjects at high risk for developing coronary heart disease. However, FRS may not accurately identify subjects at risk. We measured subclinical atherosclerosis in the coronary arteries and aorta with the presence of calcium and in the common carotid artery by intima-media thickness in 498 healthy subjects. The distribution of these subclinical atherosclerosis measures was evaluated across 3 strata of the FRS. Coronary arteries with the presence of calcium, aorta with the presence of calcium, and carotid artery by intima-media thickness were significantly independently associated with FRS. The FRS increased with the number of arterial sites with atherosclerosis; 69% of the subjects categorized in the low risk group (FRS <10%), 95% of the intermediate risk group (FRS 10% to 20%), and 100% of the high risk group (FRS >20%) had > or = 1 vascular imaging studies demonstrating subclinical atherosclerosis. In the low risk group, subjects with atherosclerosis had a longer history of lifetime smoking compared with those without atherosclerosis. In conclusion, subclinical atherosclerosis is prominent across the spectrum of FRS. Evaluation of subclinical atherosclerosis in different arterial sites in addition to FRS may be useful in targeting subjects for lifestyle and other interventions. |
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Authors:
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Roksana Karim; Howard N Hodis; Robert Detrano; Chao-Ran Liu; Chi-Hua Liu; Wendy J Mack |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2008-07-10 |
Journal Detail:
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Title: The American journal of cardiology Volume: 102 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-22 Completed Date: 2008-11-04 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 825-30 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, USA. rkarim@usc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Angiography / methods Aorta / pathology Atherosclerosis / diagnosis*, epidemiology, prevention & control Calcinosis / pathology California / epidemiology Carotid Arteries / pathology Coronary Vessels / pathology Female Humans Lipids / blood Male Middle Aged Prevalence Questionnaires Risk Assessment* Risk Factors Tomography, Spiral Computed Tunica Media / pathology Vitamin B Complex / therapeutic use |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG017160-01A1/AG/NIA NIH HHS; R01-AG17160/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 12001-76-2/Vitamin B Complex |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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