| Relation of Fibrinogen Level With Cardiovascular Events in Patients With Coronary Artery Disease. | |
| | |
MedLine Citation:
|
PMID: 23291088 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Evidence on the usefulness of fibrinogen for the risk stratification of patients with coronary artery disease remains inconclusive. The aims of this study were to investigate the association of fibrinogen with cardiovascular events and to assess whether this biomarker provides additional prognostic information on top of that provided by traditional cardiovascular risk factors. This study included 13,195 patients with angiography-proved coronary artery disease and fibrinogen measurements available. Receiver-operating characteristic curve analysis showed that the best fibrinogen cutoff for mortality prediction was 402.0 mg/dl. On the basis of this cutoff, patients were divided into 2 groups: the group with fibrinogen >402.0 mg/dl (n = 5,198) and the group with fibrinogen ≤402.0 mg/dl (n = 7,997). The primary outcome was 1-year mortality. All-cause deaths occurred in 393 patients with fibrinogen >402.0 mg/dl and in 246 patients with fibrinogen ≤402.0 mg/dl (Kaplan-Meier estimates of mortality 7.7% and 3.1%, log-rank test p <0.001). The relation between fibrinogen and mortality followed a J-shaped pattern, with lowest mortality in patients with fibrinogen concentrations of 295 to 369 mg/dl. After adjustment for cardiovascular risk factors and relevant clinical variables, fibrinogen remained an independent correlate of all-cause mortality (adjusted hazard ratio 1.07, 95% confidence interval 1.04 to 1.10, p <0.001, for each 50 mg/dl increase in fibrinogen level), but it did not improve the discriminatory power of the model for mortality prediction (integrated discrimination improvement 0.002, p = 0.32). In conclusion, in patients with coronary artery disease, fibrinogen is an independent correlate of mortality, but it does not provide additional prognostic information on top of that provided by traditional cardiovascular risk factors. |
| | |
Authors:
|
Gjin Ndrepepa; Siegmund Braun; Lamin King; Massimiliano Fusaro; Dritan Keta; Salvatore Cassese; Tomohisa Tada; Albert Schömig; Adnan Kastrati |
Related Documents
:
|
16312178 - Simplification therapy with once-daily didanosine, tenofovir and efavirenz in hiv-1-inf... 19393498 - The additive value of n-terminal pro-b-type natriuretic peptide testing at the emergenc... 10559648 - Does the plasma endothelin-1 concentration reflect atherosclerosis in the elderly? 17721028 - Diversity of the elevation of serum cardiac troponin i levels in patients during their ... 1564218 - Unstable angina: role of silent ischemia and total ischemic time (silent plus painful i... 18203308 - New onset of crohn's disease during treatment of active ankylosing spondylitis with eta... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-3 |
Journal Detail:
|
Title: The American journal of cardiology Volume: - ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2013 Elsevier Inc. All rights reserved. |
Affiliation:
|
Deutsches Herzzentrum, Technische Universität, Munich, Germany. Electronic address: ndrepepa@dhm.mhn.de. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Specialized Delivery Room Planning for Fetuses With Critical Congenital Heart Disease.
Next Document: Effect of Hurricane Katrina on Chronobiology at Onset of Acute Myocardial Infarction During the Subs...